CD93 Recombinant Monoclonal Antibody

說明書

中文名稱：

CD93重組抗體
貨號：

CSB-RA865099MA1HU
規(guī)格：

￥1320
圖片：
The Binding Activity of Macaca fascicularis CD93 with Anti-CD93 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis CD93 (CSB-MP4279MOV) at 2 μg/mL can bind Anti-CD93 recombinant antibody. The EC₅₀ is 0.1669-0.3513 ng/mL.

The Binding Activity of Human CD93 with Anti-CD93 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CD93 (CSB-MP865099HU) at 2 μg/mL can bind Anti-CD93 recombinant antibody. The EC₅₀ is 0.6639-1.173 ng/mL.

Untransfected CHO-K1*10⁶cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
其他：

產(chǎn)品詳情
產(chǎn)品評價
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靶點詳情

產(chǎn)品詳情

產(chǎn)品描述：

CD93 Recombinant Monoclonal Antibody（CSB-RA865099MA1HU）是針對CD93靶點開發(fā)的高特異性重組單克隆抗體。CD93是一種跨膜糖蛋白，廣泛表達于內(nèi)皮細胞和免疫細胞表面，參與細胞粘附、血管生成及免疫調(diào)節(jié)等生物學(xué)過程，其異常表達與炎癥反應(yīng)、腫瘤微環(huán)境調(diào)控等研究領(lǐng)域密切相關(guān)。本抗體通過ELISA等嚴格驗證，展現(xiàn)出優(yōu)異的抗原結(jié)合能力與檢測靈敏度，適用于體外實驗中CD93蛋白的定性與半定量分析。該重組抗體采用哺乳動物表達系統(tǒng)制備，具有高批次間一致性和低交叉反應(yīng)性特征，可滿足細胞功能研究、蛋白互作分析及信號通路探索等科研需求，尤其適用于血管生成相關(guān)機制研究、免疫細胞表型鑒定以及腫瘤微環(huán)境模型中CD93的功能解析。其穩(wěn)定性和可重復(fù)性為體外實驗（如細胞培養(yǎng)體系中的蛋白檢測）提供可靠工具，適用于分子生物學(xué)和細胞生物學(xué)領(lǐng)域的科研探索。
Uniprot No.：

Q9NPY3
基因名：

CD93
別名：

CD93 Recombinant Monoclonal Antibody
反應(yīng)種屬：

Human, Macaca fascicularis
免疫原：

Recombinant Human CD93 protein
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Monoclonal
抗體亞型：

hIgG1
純化方式：

Affinity-chromatography
克隆號：

15B9
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, FC

推薦稀釋比：

Application	Recommended Dilution
FC	1:20-1:200

Protocols：

ELISA Protocol
Flow cytometry (FC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion.
基因功能參考文獻：
1. Report increased CD93 expression in patients with chronic plaque psoriasis and propose the C allele of rs2749817 as a new risk allele for psoriasis. PMID: 28421233
2. Results show that CD93 and MMRN2 are co-expressed in the blood vessels of various tumors and their interaction modulates the angiogenic process. PMID: 28912033
3. These findings identify novel protein interactions involving CLEC14A, CD93 and CD248 with MMRN2 as targetable components of vessel formation PMID: 28671670
4. CD93 and Other Plasma Cell Survival Factor Genes Associated with Measles-Specific Antibody Response after Vaccination PMID: 27529750
5. Soluble expression of disulfide-bonded C-type lectin like domain of human CD93 in the cytoplasm of Escherichia coli. The recombinant protein could alter LPS pro-inflammatory activity on THP1 cells. PMID: 27742562
6. Vascular CD93 expression is elevated in nasopharyngeal carcinoma and is correlated with T classification, N classification, distant metastasis, clinical stage and poor prognosis (all P < 0.05). In addition, overexpression of CD93 promoted angiogenesis in vitro. PMID: 27255994
7. both transmembrane and soluble CD93 are overexpressed in patients with neovascular Age-Related Macular Degeneration. PMID: 27859225
8. Elevated serum sCD93 levels reflected exacerbated status of allergic diseases, including CSU [chronic spontaneous urticaria ], AR[allergic rhinitis], and asthma. ICS [inhaled corticosteroid] use significantly diminished serum sCD93 levels in steroid-naive patients with BA[Bronchial asthma]. This result may suggest sCD93 in serum as a therapeutic marker for allergic inflammation. PMID: 28332366
9. Data show that CD93 antigen proved to be phosphorylated on tyrosine 628 and 644 following cell adhesion on laminin through dystroglycan. PMID: 26848865
10. CD93 expression identifies a predominantly cycling, non-quiescent leukemia-initiating cell population in MLL-rearranged AML, providing opportunities for selective targeting and eradication of LSCs. PMID: 26387756
11. The T/T genotype of SNP rs2749817 of CD93 is associated with disseminated cancer. PMID: 26008729
12. CD93 is a key regulator of glioma angiogenesis and vascular function, acting via cytoskeletal rearrangements required for cell-cell and cell-matrix adhesion. PMID: 26363010
13. These data support a mechanism whereby gC1qR plays an important role in HPV-16 E2-induced human cervical squamous carcinoma cell apoptosis via a mitochondria-dependent pathway. PMID: 25288439
14. The data indicate that gC1qR inhibits viability, migration and proliferation of cervical squamous cells carcinoma via the p38 MAPK signalling pathway. PMID: 23052251
15. Antibody-dependent enhancement of parvovirus B19 involves an alternative mechanism mediated by the heat-sensitive complement factor C1q and its receptor, CD93. PMID: 24807719
16. Expression of CD93 on the lymphocyte population of peripheral blood cells from infants at 1 month after birth was also significantly decreased, compared with that for neonatal umbilical cord blood. PMID: 24033555
17. HPV 16 E2 induces apoptosis by silencing the gC1qR gene or inhibiting p38 MAPK/JNK signalling in cervical squamous cell carcinoma PMID: 23651874
18. These data support a mechanism whereby gC1qR induces apoptosis through the mitochondrial and p53-dependent pathways in cervical squamous cell carcinoma. PMID: 23268996
19. soluble EGF-like domain containing CD93 protein is a novel angiogenic factor acting on the endothelium PMID: 23272129
20. [review] Following a comprehensive summary of CD93 expression patterns, this review focuses on recent findings that address the putative function of CD93 in inflammation and innate immunity. PMID: 22206251
21. Data show that Pic, a class 2 SPATE protein produced by Shigella flexneri 2a targets a broad range of human leukocyte glycoproteins including CD43, CD44, CD45, CD93, CD162 and the surface-attached chemokine fractalkine. PMID: 21768350
22. Results suggest that the plasma concentration of soluble CD93 is a potential novel biomarker for Coronary Artery Disease (CAD), including MI. PMID: 21332844
23. expression on naive T lymphocytes (CD4(+)CD45RA (+) cells) in human neonatal umbilical cord blood PMID: 20512406
24. both B1 receptor and gC1q receptor are involved in the vascular leakage induced by hereditary and acquired angioedema plasma. PMID: 19796797
25. To clarify the cellular and molecular properties of C1qRp it has been demonstrated that C1q does not show enhanced binding to C1qRp-transfected cells, is not a receptor for C1q, and is identical to CD93 with functions relevant to intercellular adhesion. PMID: 11994479
26. C1qRp defines a new human stem cell population with hematopoietic and hepatic potential PMID: 12140365
27. O-glycosylation is important in the stable cell surface expression of C1qRP/CD93 PMID: 12891708
28. Taken together, these findings indicate that the expression of the CD93 molecule identified by CD93 mAb (mNI-11) is dramatically decreased on U937 cells with apoptotic properties PMID: 18094537
29. RNAi-mediated suppression of gC1qR/p32 markedly reduced HTNV binding and infection in human lung epithelial A549 cells PMID: 18834607
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亞細胞定位：

Membrane; Single-pass type I membrane protein.
組織特異性：

Highly expressed in endothelial cells, platelets, cells of myeloid origin, such as monocytes and neutrophils. Not expressed in cells of lymphoid origin.
數(shù)據(jù)庫鏈接：

HGNC: 15855

OMIM: 120577

KEGG: hsa:22918

STRING: 9606.ENSP00000246006

UniGene: Hs.97199

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