CD37 Recombinant Monoclonal Antibody
-
中文名稱：CD37重組抗體
-
貨號(hào)：CSB-RA004928MA1HU
-
規(guī)格：￥1320
-
圖片：
-
IHC image of CSB-RA004928MA1HU diluted at 1:200 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.
-
-
其他：
產(chǎn)品詳情
-
產(chǎn)品描述：CSB-RA004928MA1HU CD37重組單克隆抗體是針對(duì)人源CD37抗原設(shè)計(jì)的高特異性科研工具。CD37作為四次跨膜蛋白家族成員，在B淋巴細(xì)胞表面特異性表達(dá)，參與調(diào)控細(xì)胞黏附、遷移及信號(hào)轉(zhuǎn)導(dǎo)，其異常表達(dá)與B細(xì)胞淋巴瘤等疾病密切相關(guān)。本抗體經(jīng)ELISA及免疫組化（IHC）雙重平臺(tái)驗(yàn)證，在IHC應(yīng)用中可清晰顯示石蠟包埋組織中B淋巴細(xì)胞的膜定位特征，推薦使用稀釋度為1:50-1:200，能有效區(qū)分目標(biāo)蛋白的組織分布差異。ELISA檢測(cè)體系顯示其具備出色的線性反應(yīng)范圍，適用于體外樣本的定量分析。該產(chǎn)品可為B細(xì)胞發(fā)育分化研究、淋巴瘤微環(huán)境分析、免疫細(xì)胞表面標(biāo)記物檢測(cè)等實(shí)驗(yàn)提供可靠支持，尤其在探究B細(xì)胞相關(guān)疾病的分子機(jī)制、篩選潛在治療靶點(diǎn)及開(kāi)發(fā)體外檢測(cè)方法等領(lǐng)域具有重要應(yīng)用價(jià)值。通過(guò)嚴(yán)格的抗原親和純化工藝，確保批次間穩(wěn)定性，適用于需要高重復(fù)性的長(zhǎng)期研究項(xiàng)目。
-
Uniprot No.：
-
基因名：
-
別名：CD37 Recombinant Monoclonal Antibody
-
反應(yīng)種屬：Human
-
免疫原：Recombinant Human CD37 protein
-
免疫原種屬：Homo sapiens (Human)
-
標(biāo)記方式：Non-conjugated
-
克隆類型：Monoclonal
-
抗體亞型：hIgG1
-
純化方式：Affinity-chromatography
-
克隆號(hào)：9H6
-
濃度：It differs from different batches. Please contact us to confirm it.
-
保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式：Liquid
-
應(yīng)用范圍：ELISA, IHC
-
推薦稀釋比：
Application Recommended Dilution IHC 1:50-1:200 -
Protocols：
-
儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
-
用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
-
基因功能參考文獻(xiàn)：
- CD37 is a critical determinant of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone outcome in diffuse large B-cell lymphoma. PMID: 27760757
- Data indicate that cell differentiation antigen 37 (CD37) is well expressed and a potential drug target in acute myeloid leukemia (AML). PMID: 25934707
- The CD37-targeted antibody-drug conjugate IMGN529 is highly active against human CLL and in a novel CD37 transgenic murine leukemia model. PMID: 24445867
- Data indicate that enhanced antibody-dependent cell cytotoxicity (ADCC) is observed against chronic lymphocytic leukemia cells and is sustained at concentrations of SMIP-016(GV) as low at 5E(-6) microg/mL on cells expressing minimal CD37 antigen. PMID: 23883821
- Identify two tyrosine residues in tetraspanin CD37 directly mediating transduction of survival and apoptotic signals. PMID: 22624718
- In the absence of both CD37 and Tssc6, immune function is further altered when compared with CD37- or Tssc6-deficient transgenic mice, demonstrating a complementary role for these two molecules in cellular immunity. PMID: 20709950
- CD37 cross-linking on human T cells transduces signals that lead to complete inhibition of CD3-induced T cell proliferation. PMID: 14978098
- CD37 is important for dectin-1 stabilization in APC membranes and controls dectin-1-mediated IL-6 production. PMID: 17182550
- provide strong justification for CD37 as a therapeutic target and introduce small modular immunopharmaceuticals as a novel class of targeted therapies for B-cell malignancies PMID: 17440052
顯示更多
收起更多
-
亞細(xì)胞定位：Membrane; Multi-pass membrane protein.
-
蛋白家族：Tetraspanin (TM4SF) family
-
組織特異性：B-lymphocytes.
-
數(shù)據(jù)庫(kù)鏈接：
Most popular with customers
-
-
YWHAB Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC, IF, FC
Species Reactivity: Human, Mouse, Rat
-
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC
Species Reactivity: Human
-
-
-
-
-
