CCR8 Recombinant Monoclonal Antibody

說明書

中文名稱：

CCR8重組抗體
貨號：

CSB-RA004847MA4HU
規格：

￥1320
圖片：
Untransfected HEK293T cells surface(green line) and transfected Human CCR8 HEK293T stable cells surface (red line) were stained with anti-CCR8 recombinant antibody (2μg/1*10⁶cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

Untransfected CHO-K1 cells surface (green line) and transfected Human CCR8 CHO-K1 stable cells surface (red line) were stained with anti-CCR8 recombinant antibody (2μg/1*10⁶cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品描述：

CSB-RA004847MA4HU是針對人CCR8蛋白研發的重組單克隆抗體，靶向該趨化因子受體的特異性表位。CCR8作為G蛋白偶聯受體家族成員，在調節性T細胞（Treg）及腫瘤相關巨噬細胞中高表達，通過介導CCL1等配體信號傳導參與免疫抑制微環境的形成，在腫瘤免疫逃逸和炎癥性疾病中發揮重要作用。本抗體經流式細胞術（FC）嚴格驗證，展示出優異的抗原結合能力與批次間穩定性，適用于體外細胞表面標志物檢測。科研領域可用于：1）腫瘤微環境中免疫抑制性細胞的表型分析；2）Treg細胞功能調控機制研究；3）構建CCR8相關信號通路的體外模型；4）評估免疫檢查點調控藥物對CCR8+細胞亞群的影響。該產品采用重組表達技術生產，具有高純度、低內毒素特性，適用于流式細胞分析等基礎研究中的細胞表面蛋白檢測需求。
Uniprot No.：

P51685
基因名：

CCR8
別名：

C C chemokine receptor type 8 antibody; C C CKR 8 antibody; C C motif chemokine receptor 8 antibody; C-C chemokine receptor type 8 antibody; C-C CKR-8 antibody; CC chemokine receptor 8 antibody; CC chemokine receptor CHEMR1 antibody; CC chemokine receptor type 8 antibody; CC CKR 8 antibody; CC-CKR-8 antibody; CCR 8 antibody; CCR-8 antibody; Ccr8 antibody; CCR8 protein antibody; CCR8-L antibody; CCR8_HUMAN antibody; CDw198 antibody; CDw198 antigen antibody; Chemokine (C C motif) receptor 8 antibody; Chemokine (C C) receptor 8 antibody; Chemokine (C C) receptor like 2 antibody; Chemokine (CC motif) receptor 8 antibody; Chemokine (CC) receptor 8 antibody; Chemokine (CC) receptor like 1 antibody; Chemokine (CC) receptor like 2 antibody; Chemokine C C motif receptor 8 antibody; Chemokine C C receptor 8 antibody; Chemokine CC motif receptor 8 antibody; Chemokine CC receptor 8 antibody; Chemokine receptor 8 antibody; Chemokine receptor like 1 antibody; Chemokine receptor-like 1 antibody; CKR L1 antibody; CKR-L1 antibody; CKRL 1 antibody; CKRL1 antibody; CMKBR 8 antibody; CMKBR L2 antibody; CMKBR8 antibody; CMKBRL 2 antibody; CMKBRL2 antibody; CY 6 antibody; CY6 antibody; GPR CY6 antibody; GPR-CY6 antibody; GPRCY6 antibody; MGC123958 antibody; MGC123959 antibody; MGC129966 antibody; MGC129973 antibody; TER 1 antibody; TER1 antibody
反應種屬：

Human
免疫原：

Recombinant Human CCR8 protein
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Monoclonal
抗體亞型：

hIgG1，lambda 2
純化方式：

Affinity-chromatography
克隆號：

10A9
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

FC
Protocols：

Flow cytometry (FC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection.
基因功能參考文獻：
1. Authors demonstrate the pivotal role of CCR8(+) Treg cells in restraining immunity and highlight the potential clinical implications of this discovery. PMID: 28533380
2. Role of Conserved Disulfide Bridges and Aromatic Residues in Extracellular Loop 2 of Chemokine Receptor CCR8 for Chemokine and Small Molecule Binding. PMID: 27226537
3. High CCR8 expression is associated with high recurrence in kidney cancer. PMID: 26716905
4. findings suggest that CCR8 expression in ALCL is more closely related to the presence of DUSP22 rearrangements than to cutaneous involvement and that the function of CCR8 may extend beyond its skin-homing properties in this disease PMID: 25390351
5. Epidermal-derived vitamin D3 metabolites and prostaglandins provide an essential cue for the localization of CCR8+ immune surveillance T cells within healthy human skin. PMID: 26002980
6. CCL1-CCR8 interaction may play a critical role in lymphocytic recruitment in IgG4-related sclerosing cholangitis and type 1 autoimmune pancreatitis, leading to duct-centred inflammation and obliterative phlebitis. PMID: 23811304
7. Identification of human CCR8 as a CCL18 receptor. PMID: 23999500
8. CCR8(+) myeloid cell subset is expanded in patients with cancer. PMID: 23363815
9. Data show that CCR8 expression by newly activated naive T cells is regulated by skin-specific factor(s) derived primarily from epidermal keratinocytes. PMID: 23043070
10. C-terminal clipping of chemokine CCL1/I-309 enhances CCR8-mediated intracellular calcium release and anti-apoptotic activity PMID: 22479563
11. The functional data from human macrophages suggest a potential cross talk between the CCR8 and the Toll-like receptor 4 (TLR4) pathways, both of which are present in chronic obstructive pulmonary disease patients. PMID: 21976223
12. There may be a role for CCR8 in the recruitment of T cells to the lung in asthmatics. PMID: 20455898
13. CCR8 mediates rescue from dexamethasone-induced apoptosis via an ERK-dependent pathway PMID: 12525579
14. found in the central nervous system and is associated with phagocytic macrophages PMID: 12547701
15. CCR8 genes and surrounding genomic regions these genes are the result of the duplication of an ancestral gene prior to the divergence of teleost fish. PMID: 12551893
16. Transfected human CCR8-dependent activation of the RAS/MAPK pathway mediates anti-apoptotic activity of I-309/ CCL1 and vMIP-I. PMID: 12645948
17. The induction of CCR8 under conditions associated with vascular smooth muscle cell proliferation and migration raises the possibility that CCR8 may play an important role in vessel wall pathology. PMID: 14576057
18. the axis CCL1-CCR8 links adaptive and innate immune functions that play a role in the initiation and amplification of atopic skin inflammation PMID: 15814739
19. CCR8 ligands are allotropic, binding to distinct sites within CCR8; the human immune system may have evolved to use CCL7 as a selective antagonist of viral chemokine activity at CCR8 but not those of the host ligand PMID: 17023422
20. CCR8 is expressed by a small and heterogeneous population of peripheral blood CD4 memory T cells enriched in T helper type 2 (Th2) effector and T regulatory (Treg) cells. PMID: 17082609
21. CCR8-expressing CD4-positive T lymphocytes are preferentially recruited from the periphery into the lungs of asthmatic individuals, driven by elevated CCL1 levels produced almost exclusively by mast cells and basophils. PMID: 17641040
22. The combination of 17beta-E(2) with the environmental pollutant TCDD is involved in the pathogenesis of endometriosis via up-regulating the chemokine CCR8-I-309. PMID: 17693327
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亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor 1 family
數據庫鏈接：

HGNC: 1609

OMIM: 601834

KEGG: hsa:1237

STRING: 9606.ENSP00000326432

UniGene: Hs.113222

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