ptxA Antibody

Name: ptxA Antibody
Brand: CUSABIO
SKU: CSB-PA356423LA01Bua

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說明書

產品詳情

產品描述：

The ptxA antibody is a polyclonal antibody produced in rabbit, which specifically binds to the Bordetella pertussis ptxA protein. The immunogen is a synthetic peptide mapping to the amino acids 35-269 of the recombinant Bordetella pertussis Pertussis toxin subunit 1 protein. The antibody has been purified using protein G affinity chromatography, resulting in a purity level greater than 95%. The antibody is of the IgG class and is unconjugated, meaning it can be used in a wide range of applications.

The ptxA antibody has been validated for use in both ELISA and WB applications. As a result, it is a valuable tool for researchers investigating Bordetella pertussis ptxA and its role in the pathogenesis of whooping cough.
產品名稱：

Rabbit anti-Bordetella pertussis ptxA Polyclonal antibody
Uniprot No.：

P04977
基因名：

ptxA
別名：

ptxA antibody; BP3783 antibody; Pertussis toxin subunit 1 antibody; PTX S1 antibody; Islet-activating protein S1 antibody; IAP S1 antibody; NAD-dependent ADP-ribosyltransferase antibody; EC 2.4.2.- antibody
宿主：

Rabbit
反應種屬：

Bordetella pertussis
免疫原：

Recombinant Bordetella pertussis Pertussis toxin subunit 1 protein (35-269AA)
免疫原種屬：

Bordetella pertussis

標記方式：

Non-conjugated

本頁面中的產品，ptxA Antibody (CSB-PA356423LA01Bua)，的標記方式是Non-conjugated。對于ptxA Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA356423LB01Bua	ptxA Antibody, HRP conjugated	ELISA
FITC	CSB-PA356423LC01Bua	ptxA Antibody, FITC conjugated
Biotin	CSB-PA356423LD01Bua	ptxA Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

S1 is an NAD-dependent ADP-ribosyltransferase, which plays a crucial role in the pathogenesis of B.pertussis causing disruption of normal host cellular regulation. It catalyzes the ADP-ribosylation of a cysteine in the alpha subunit of host heterotrimeric G proteins. In the absence of G proteins it also catalyzes the cleavage of NAD(+) into ADP-ribose and nicotinamide. It irreversibly uncouples the G-alpha GTP-binding proteins from their membrane receptors.
基因功能參考文獻：
1. It has been proposed that it is the systemic activity of pertussis toxin and not pulmonary pathology that promotes mortality in critical pertussis. PMID: 28784932
亞細胞定位：

Secreted. Note=The individual chains are secreted by a sec-dependent mechanism into the periplasm. Then, S1 associates with the outer membrane before it joins with the B subunit to form the secretion-competent holotoxin. The type IV secretion system ptl mediates secretion of assembled toxin through the outer membrane.
蛋白家族：

Bacterial exotoxin subunit A family
數據庫鏈接：

KEGG: bpe:BP3783

STRING: 257313.BP3783

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