nikR Antibody, Biotin conjugated

^{Rare Species}

說明書

產品詳情

產品名稱：

Rabbit anti-Escherichia coli nikR Polyclonal antibody
Uniprot No.：

P0A6Z6
基因名：

nikR
別名：

nikR antibody; yhhG antibody; b3481 antibody; JW3446Nickel-responsive regulator antibody
宿主：

Rabbit
反應種屬：

Escherichia coli
免疫原：

Recombinant Escherichia coli Nickel-responsive regulator protein (1-133AA)
免疫原種屬：

Escherichia coli
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Transcriptional repressor of the nikABCDE operon. Is active in the presence of excessive concentrations of intracellular nickel.
基因功能參考文獻：
1. Structural basis of low-affinity nickel binding to the nickel-responsive transcription factor NikR from Escherichia coli PMID: 20704276
2. localized this Ni(II) site to a region at the interface between the metal- and DNA-binding domains and identified His48 and His110 as residues that participate in the low-affinity Ni(II)-binding response PMID: 20583753
3. Mutagenesis and cation exchange experiments reveal that K(+) is a critical structural component for the activation of Ni(II)-responsive DNA binding by NikR. PMID: 20088519
4. This data sheds light on the Ni(II)-selective conformational changes that allow NikR to bind DNA optimally and repress transcription of the nik operon. PMID: 16133200
5. Two crystal structures of nickel-activated E. coli NikR were reported. PMID: 16945905
6. NikR response is specific to nickel in vivo. PMID: 17397155
7. Results examine a series of residue interrelationships that describe an allosteric communication pathway between the Ni(2+)- and DNA-binding sites of NikR, which are separated by 40 A. PMID: 18433769
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蛋白家族：

Transcriptional regulatory CopG/NikR family
數據庫鏈接：

KEGG: ecj:JW3446

STRING: 316385.ECDH10B_3655

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