mutL Antibody, Biotin conjugated

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說明書

中文名稱：

mutL兔多克隆抗體, Biotin偶聯(lián)
貨號：

CSB-PA543397HD01ENV
規(guī)格：

￥880
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Escherichia coli mutL Polyclonal antibody
Uniprot No.：

P23367
基因名：

mutL
別名：

mutL antibody; b4170 antibody; JW4128 antibody; DNA mismatch repair protein MutL antibody
宿主：

Rabbit
反應種屬：

Escherichia coli
免疫原：

Recombinant Escherichia coli DNA mismatch repair protein MutL protein (1-615AA)
免疫原種屬：

Escherichia coli
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of the final effector complex. The ATPase activity of MutL is stimulated by DNA.
基因功能參考文獻：
1. In this review, we describe biochemical, biophysical and structural analyses that have clarified how MutL aids at discriminating the newly synthesized strand from its template and marking it for removal. [review] PMID: 25701376
2. study found the deletion or insertion of a single LA repeat did not compromise the structural integrity of the protein, nor did it affect MutS- or DNA-binding activity;it severely compromised ATP binding and engagement of the N-terminal domains; both essential activities for proper DNA mismatch repair PMID: 23916559
3. MutL accumulates from the mismatch site toward strand discrimination site along the DNA. PMID: 22241777
4. Evidence for ATP-dependent structural rearrangement of nuclease catalytic site in DNA mismatch repair endonuclease MutL PMID: 21953455
5. C-terminal domain of MutL encompasses a bona fide DNA polymerase III beta-binding motif that mediates a weak, yet specific, interaction between the two proteins. PMID: 21050827
6. The presence of phosphate minimizes further MutL oligomerization beyond a dimer PMID: 21793594
7. Studies indicate that a stable MutL-ssDNA interaction is unlikely to occur at physiological salt. PMID: 21103398
8. MutL homologues play a key role in determining biologic outcome by recruiting and/or activating effector proteins in response to lesion recognition by MutS. PMID: 19953589
9. Data report the crystal structure of the Escherichia coli MutL C-terminal dimerization domain and the likelihood of its conservation among MutL homologs. PMID: 15470502
10. revised model for the biological dimer, which has important implications for understanding the heterodimerization of eukaryotic MutL homologues, modeling the MutL holoenzyme and predicting protein-protein interaction sites PMID: 16024043
11. MutL determines effective DNA homology in recombination processes PMID: 17502621
12. An increase in mutL gene copies was also able to partially compensate the hypermutator phenotype of a mutS-defective E. coli derivative. PMID: 17825069
13. Results suggest a mobile MutS-MutL complex in DNA mismatch repair signalling, that leaves the DNA mismatch prior to, or at the time of, activation of downstream effector molecules such as Vsr or MutH. PMID: 19474347
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蛋白家族：

DNA mismatch repair MutL/HexB family
數(shù)據(jù)庫鏈接：

KEGG: ecj:JW4128

STRING: 316385.ECDH10B_4365

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