isl1 Antibody, Biotin conjugated

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說明書

中文名稱：

isl1兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA011846LD01DIL
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Danio rerio (Zebrafish) (Brachydanio rerio) isl1 Polyclonal antibody
Uniprot No.：

P53405
基因名：

isl1
別名：

isl1 antibody; isl-1 antibody; si:ch211-219f7.1 antibody; Insulin gene enhancer protein isl-1 antibody; Islet-1 antibody
宿主：

Rabbit
反應種屬：

Zebrafish
免疫原：

Recombinant Zebrafish Insulin gene enhancer protein isl-1 protein (1-349AA)
免疫原種屬：

Danio rerio (Zebrafish) (Brachydanio rerio)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. May be involved in subtype specialization of primary motoneurons. May bind to insulin gene enhancer sequences. Essential for heart development.
基因功能參考文獻：
1. ISL1 is a major susceptibility gene for bladder exstrophy and a regulator of urinary tract development. PMID: 28176844
2. Nkx2-5 and nkx2.7 genes restrict proliferation of heart field progenitors in the outflow tract, delimit the number of progenitors at the venous pole and pattern the sinoatrial node acting through Isl1 repression. PMID: 29361575
3. Arx contributes to patterning in the prethalamic region, while Isl1 is required for differentiation of prethalamic dopaminergic neurons. PMID: 22728160
4. Ajuba plays a central role in regulating the second heart field during heart development by linking retinoic acid signaling to the function of Isl1, a key transcription factor in cardiac progenitor cells. PMID: 22771034
5. Isl1 is required for the selective outgrowth of the peripheral axons of Rohon-beard neurons. PMID: 21108318
6. prdm1a Regulates sox10 and islet1 in the development of neural crest and Rohon-Beard sensory neurons. PMID: 20836130
7. By direct comparison of the upstream flanking regions of the zebrafish and human isl1 genes, we identified another highly conserved noncoding element. PMID: 15680372
8. primary motoneuron subtypes are likely to be specified by factors that act in parallel to or upstream of islet1 and islet2 PMID: 16672347
9. Nkx6 proteins regulate MiP motorneuron development at least in part by maintaining the islet1 expression that is required both to promote the MiP subtype and to suppress interneuron development. PMID: 17376808
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亞細胞定位：

Nucleus.
數據庫鏈接：

KEGG: dre:30147

STRING: 7955.ENSDARP00000012903

UniGene: Dr.75106

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