cyp125 Antibody

Name: cyp125 Antibody
Brand: CUSABIO
SKU: CSB-PA351308HA01MVZ

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說明書

產品詳情

產品名稱：

Rabbit anti-Mycobacterium tuberculosis cyp125 Polyclonal antibody
Uniprot No.：

P9WPP1
基因名：

cyp125
別名：

cyp125 antibody; cyp125A1 antibody; Rv3545c antibody; MTCY03C7.11Steroid C26-monooxygenase antibody; EC 1.14.15.29 antibody; Cholest-4-en-3-one 26-monooxygenase antibody; Cholest-4-en-3-one C26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming] antibody; Cholesterol C26-monooxygenase antibody; Cholesterol C26-monooxygenase [(25S)-3beta-hydroxycholest-5-en-26-oate forming] antibody; Cytochrome P450 125 antibody; Steroid C27-monooxygenase antibody
宿主：

Rabbit
反應種屬：

Mycobacterium tuberculosis
免疫原：

Recombinant Mycobacterium tuberculosis Steroid C26-monooxygenase protein (1-433AA)
免疫原種屬：

Mycobacterium tuberculosis

標記方式：

Non-conjugated

本頁面中的產品，cyp125 Antibody (CSB-PA351308HA01MVZ)，的標記方式是Non-conjugated。對于cyp125 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA351308HB01MVZ	cyp125 Antibody, HRP conjugated	ELISA
FITC	CSB-PA351308HC01MVZ	cyp125 Antibody, FITC conjugated
Biotin	CSB-PA351308HD01MVZ	cyp125 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain during infection. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25S)-26-hydroxycholest-4-en-3-one (alcohol), (25S)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25S)-3-oxocholest-4-en-26-oate. Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one.
基因功能參考文獻：
1. M. tuberculosis cytochrome P450 Cyp125 plays a key role in cholesterol metabolism being involved in the first steps of its degradation PMID: 26197389
2. Drug modulation of water-heme interactions in low-spin P450 complexes of CYP2C9d and CYP125A1. PMID: 25591012
3. CYP125A1 plays a crucial role in circumventing the deleterious effect of cholest-4-en-3-one. PMID: 20545858
4. Reactive nitrogen species (*NO) produced by host macrophages binds to CYP125 in its ferric state; a role for *NO in inhibition of cytochrome P450 activities in dormant mycobacterial cells is conceivable. PMID: 19146393
5. Mycobacterial cytochrome p450 125 (cyp125) catalyzes the terminal hydroxylation of c27 steroids. PMID: 19846551
6. The Structure of Mycobacterium tuberculosis CYP125: molecular basis for cholesterol binding in a P450 needed for host infection. PMID: 19846552
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蛋白家族：

Cytochrome P450 family
數據庫鏈接：

KEGG: mtu:Rv3545c

STRING: 83332.Rv3545c

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