ZRSR2 Antibody

中文名稱：

ZRSR2兔多克隆抗體
貨號：

CSB-PA618014LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA618014LA01HU at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品描述：

The product CSB-PA618014LA01HU is a polyclonal antibody raised in the rabbit with a peptide covering amino acids 191-372 of the human ZRSR2 protein immunized. The ZRSR2 antibody exists as an unconjugated IgG. It can specifically bind to the ZRSR2 protein, a splicing factor involved in the recognition of 3′-intron splice sites during the early stages of spliceosome assembly. This anti-ZRSR2 antibody has undergone quality tested for use in common research applications, including ELISA, WB, IHC, and IF. Its purity is over 95% using protein G purified. And it is reactive with human and mouse samples.
產品名稱：

Rabbit anti-Homo sapiens (Human) ZRSR2 Polyclonal antibody
Uniprot No.：

Q15696
基因名：

ZRSR2
別名：

CCCH type zinc finger antibody; CCCH type zinc finger; RNA binding motif and serine/arginine rich protein 2 antibody; MGC142014 antibody; MGC142040 antibody; Renal carcinoma antigen NY REN 20 antibody; Renal carcinoma antigen NY-REN-20 antibody; RNA-binding motif and serine/arginine rich protein 2 antibody; U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit related protein 2 antibody; U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 antibody; U2(RNU2) small nuclear RNA auxiliary factor 1 like 2 antibody; U2(RNU2) small nuclear RNA auxiliary factor 1-like 2 antibody; U2AF1 RS2 antibody; U2AF1L2 antibody; U2AF1RS2 antibody; U2AF35-related protein antibody; U2AFM_HUMAN antibody; URP antibody; Zinc finger-; CCCH domain-; and RNA-binding motif-containing serine/arginine-rich protein 2 antibody; Zrsr2 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 protein (191-372AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，ZRSR2 Antibody (CSB-PA618014LA01HU)，的標記方式是Non-conjugated。對于ZRSR2 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA618014LB01HU	ZRSR2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA618014LC01HU	ZRSR2 Antibody, FITC conjugated
Biotin	CSB-PA618014LD01HU	ZRSR2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3'-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP-dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing.
基因功能參考文獻：
1. We conclude that the common clinical features of patients with an isolated mutation of ZRSR2 are a macrocytic anemia without leukopenia, thrombocytopenia or an increase in marrow blast percentage PMID: 28942350
2. ZRSR2 has a role in RNA splicing; dysregulated splicing of U12-type introns is a characteristic feature of ZRSR2 mutations in myelodysplastic syndrome PMID: 25586593
3. Data show that through recognition of a common splicing element, Urp facilitates distinct steps of U2- and U12-type intron splicing. PMID: 21041408
亞細胞定位：

Nucleus.
組織特異性：

Widely expressed.
數據庫鏈接：

HGNC: 23019

OMIM: 300028

KEGG: hsa:8233

STRING: 9606.ENSP00000303015

UniGene: Hs.171909

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