ZRANB3 Antibody

中文名稱：

ZRANB3兔多克隆抗體
貨號：

CSB-PA705058LA01HU
規(guī)格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA705058LA01HU at dilution of 1:100
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) ZRANB3 Polyclonal antibody
Uniprot No.：

Q5FWF4
基因名：

ZRANB3
別名：

4933425L19Rik antibody; AH2 antibody; Annealing helicase 2 antibody; DNA annealing helicase and endonuclease ZRANB3 antibody; MGC105033 antibody; MGC75012 antibody; OTTHUMP00000197449 antibody; Zinc finger Ran-binding domain-containing protein 3 antibody; Zinc finger; RAN- binding domain containing 3 antibody; ZRAB3_HUMAN antibody; Zranb3 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human DNA annealing helicase and endonuclease ZRANB3 protein (370-624AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，ZRANB3 Antibody (CSB-PA705058LA01HU)，的標記方式是Non-conjugated。對于ZRANB3 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA705058LB01HU	ZRANB3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA705058LC01HU	ZRANB3 Antibody, FITC conjugated
Biotin	CSB-PA705058LD01HU	ZRANB3 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks.
基因功能參考文獻：
1. PCNA and ATP-dependency serve as a multi-layered regulatory mechanism that modulates ZRANB3 activity at replication forks. PMID: 28621305
2. A large number of SNF2 family, DNA and ATP-dependent motor proteins are needed during transcription, DNA replication, and DNA repair to manipulate protein-DNA interactions and change DNA structure. SMARCAL1, ZRANB3, and HLTF are three related members of this family with specialized functions that maintain genome stability during DNA replication. [review] PMID: 28954549
3. depletion of SMARCAL1, a SNF2-family DNA translocase that remodels stalled forks, restores replication fork stability and reduces the formation of replication stress-induced DNA breaks and chromosomal aberrations in BRCA1/2-deficient cells. In addition to SMARCAL1, other SNF2-family fork remodelers, including ZRANB3 and HLTF, cause nascent DNA degradation and genomic instability PMID: 29053959
4. Damage-induced fork reversal in mammalian cells requires PCNA ubiquitination, UBC13, and K63-linked polyubiquitin chains, previously involved in error-free damage tolerance. Fork reversal in vivo also requires ZRANB3 translocase activity and its interaction with polyubiquitinated PCNA, pinpointing ZRANB3 as a key effector of error-free DNA damage tolerance. PMID: 28886337
5. Here is described a substrate recognition domain within ZRANB3 that is needed for it to recognize forked DNA structures, hydrolyze ATP, catalyze fork remodeling, and act as a structure-specific endonuclease. PMID: 26884333
6. ZRANB3 translocase, a SNF2 family member related to the SIOD disorder SMARCAL1 protein, is recruited by polyubiquitinated PCNA to promote fork restart following replication arrest. PMID: 22704558
7. AH2 is recruited to stalled replication forks and that cells depleted of AH2 are hypersensitive to replication stresses. PMID: 22705370
8. a role for ZRANB3 in the replication stress response and suggest new insights into how DNA repair is coordinated with DNA replication to maintain genome stability. PMID: 22759634
9. structural and functional differences between AH2 and HARP suggest that different annealing helicases have distinct functions in the cell. PMID: 21078962
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亞細胞定位：

Nucleus. Chromosome.
蛋白家族：

SNF2/RAD54 helicase family
數(shù)據(jù)庫鏈接：

HGNC: 25249

OMIM: 615655

KEGG: hsa:84083

STRING: 9606.ENSP00000264159

UniGene: Hs.658422

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