ZP4 Antibody

中文名稱：

ZP4兔多克隆抗體
貨號：

CSB-PA621518LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA621518LA01HU diluted at 1:300 and staining in paraffin-embedded human ovarian tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) ZP4 Polyclonal antibody
Uniprot No.：

Q12836
基因名：

ZP4
別名：

Processed zona pellucida sperm-binding protein 4 antibody; ZBP antibody; Zona pellucida B protein antibody; Zona pellucida glycoprotein 4 antibody; Zona pellucida protein B antibody; Zona pellucida sperm binding protein 4 antibody; Zp-4 antibody; ZP1 antibody; ZP4 antibody; ZP4_HUMAN antibody; ZPB antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Zona pellucida sperm-binding protein 4 protein (368-457AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，ZP4 Antibody (CSB-PA621518LA01HU)，的標記方式是Non-conjugated。對于ZP4 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA621518LB01HU	ZP4 Antibody, HRP conjugated	ELISA
FITC	CSB-PA621518LC01HU	ZP4 Antibody, FITC conjugated
Biotin	CSB-PA621518LD01HU	ZP4 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:200-1:500

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor.
基因功能參考文獻：
1. ZO4 is highly expressed in ovarian tissue in PCOS patients with regular cycle and without hyperandrogenism; in some patients with PCOS and infertility, ZP4 mutation can be found. PMID: 25740067
2. Human ZP4 is not sufficient to support human sperm binding to the zona pellucida in transgenic mice; other zona proteins may be needed for human gamete recognition. PMID: 21173071
3. ZPB induces acrosomal exocytosis through a Gi independent pathway. PMID: 15805145
4. Binding sites for recombinant zona pellucida B (ZPB) glycoprotein are located both at the N- and C-terminus of proacrosin PMID: 15950651
5. Exposure of sperm to ZP proteins promoted acrosomal exocytosis and changed motility patterns. PMID: 16407501
6. induces acrosome reactions which are protein kinase-C, protein tyrosine kinase, T-type Ca2+ channels, and extracellular Ca2+ dependent PMID: 18667750
7. a significant decrease in acrosomal exocytosis mediated by both recombinant human ZP3 (p<0.005) and ZP4 (p<0.005) was observed in presence of the immune sera PMID: 19004505
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亞細胞定位：

[Processed zona pellucida sperm-binding protein 4]: Zona pellucida.; Cell membrane; Single-pass type I membrane protein.
蛋白家族：

ZP domain family, ZPB subfamily
組織特異性：

Expressed in oocytes.
數據庫鏈接：

HGNC: 15770

OMIM: 613514

KEGG: hsa:57829

STRING: 9606.ENSP00000355529

UniGene: Hs.136241

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