ZNRD1 Antibody

中文名稱：

ZNRD1兔多克隆抗體
貨號：

CSB-PA885791HA01HU
規格：

￥440
圖片：
Western blot
All lanes: ZNRD1 antibody at 14µg/ml + Human high value serum
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 14 kDa
Observed band size: 14 kDa
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) ZNRD1 Polyclonal antibody
Uniprot No.：

Q9P1U0
基因名：

ZNRD1
別名：

DNA directed RNA polymerase I subunit RPA12 antibody; DNA-directed RNA polymerase I subunit RPA12 antibody; HTEX 6 antibody; hZR14 antibody; RNA polymerase I small specific subunit Rpa12 antibody; RPA12 antibody; RPA12_HUMAN antibody; tctex 6 antibody; TCTEX6 antibody; TEX6 antibody; Transcription associated zinc ribbon protein antibody; Zinc ribbon domain containing 1 antibody; Zinc ribbon domain containing protein 1 antibody; Zinc ribbon domain-containing protein 1 antibody; ZNRD1 antibody; ZR14 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human DNA-directed RNA polymerase I subunit RPA12 protein (1-126AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，ZNRD1 Antibody (CSB-PA885791HA01HU)，的標記方式是Non-conjugated。對于ZNRD1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA885791HB01HU	ZNRD1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA885791HC01HU	ZNRD1 Antibody, FITC conjugated
Biotin	CSB-PA885791HD01HU	ZNRD1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors.
基因功能參考文獻：
1. Findings suggest a tumor suppressor function for ZNRD1 gene and a tumor contributor function for long noncoding RNAs (IncRNAs) ZNRD1-AS1 in the process of carcinogenesis of lung cancer. PMID: 27166266
2. ZNRD1 regulatory SNPs may be susceptibility makers for risk of both chronic HBV infection and HCC. PMID: 25110835
3. This study provides novel evidence that ZNRD1 polymorphism may confer host resistance to HIV-1 acquisition. PMID: 24842830
4. A miR-508-5p/ZNRD1/ABCB1 regulatory loop has a critical role in MDR in gastric cancer. PMID: 23893241
5. Variants in ZNRD1 gene predict HIV-1/AIDS disease progression in a Han Chinese population in Taiwan. PMID: 23874430
6. Nominal associations were found between ZNRD1 rs1150740 and risk of AERD via codominant and dominant genetic inheritance (P=.03; odds ratio, 1.14 [1.14-10.16]). PMID: 22697009
7. The results of human miRNA array and real-time PCR showed that ZNRD1 could significantly up-regulate the expression of miR-214 and down-regulate the expression of miR-296. PMID: 21080911
8. siRNA-based functional analysis showed that ZNRD1 down-regulation by siRNA or shRNA impaired HIV-1 replication at the transcription level in both lymphoid and nonlymphoid cells. PMID: 20192730
9. ZNRD1 gene displays high expression in VCR resistant gastric cancer cells. PMID: 12795835
10. overexpression of ZNRD1 could promote multidrug-resistant phenotype of gastric cancer cells through upregulation of P-glycoprotein PMID: 14726695
11. This study clearly demonstrates that ZNRD1 may play an important role in the control of human gastric cancer development by regulating cell proliferation. PMID: 15358150
12. ZNRD1 may play an important role in the regulation of gastric carcinogenesis and could be used as a new target in treatment of stomach cancer PMID: 15662122
13. ZNRD1 significantly inhibits the in vitro and in vivo growth of human gastric cancer cell line MKN28 by targeting cell cycle-related genes and reducing tumor angiogenesis. PMID: 17389617
14. The up-regulation of ZNRD1 significantly inhibited the drug sensitivity of gastric cancer cells over-expressing DARPP-32, indicating that ZNRD1 may be important in the DARPP-32-mediated MDR of gastric cancer PMID: 17492506
15. DARPP-32 mediates multidrug resistance of gastric cancer through regulation of P-gp and ZNRD1. PMID: 18058465
16. ZNRD1-expressing cells exhibited enhanced DNA repair capacity and overexpression could upregulate the expression of excision repair cross-complementing 1 (ERCC1) gene PMID: 18564169
17. ZNRD1 was down-regulated in esophageal cancer tissues compared to adjacent non-neoplastic tissues. PMID: 18594968
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亞細胞定位：

Nucleus, nucleolus.
蛋白家族：

Archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family
數據庫鏈接：

HGNC: 13182

OMIM: 607525

KEGG: hsa:30834

STRING: 9606.ENSP00000331111

UniGene: Hs.57813

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