ZNF148 Antibody

說明書

中文名稱：

ZNF148兔多克隆抗體
貨號：

CSB-PA004559
規格：

￥1090
圖片：
Western Blot analysis of HepG2 cells using ZBP-89 Polyclonal Antibody
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q9UQR1
基因名：

ZNF148
別名：

Transcription factor ZBP-89 antibody; Transcription factor ZBP89 antibody; ZBP89 antibody; Zinc finger DNA binding protein 89 antibody; Zinc finger DNA-binding protein 89 antibody; Zinc finger protein 148 antibody; ZN148_HUMAN antibody; ZNF 148 antibody; ZNF148 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from the N-terminal region of Human ZBP-89.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, IHC, IF, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:100-1:300
IF	1:200-1:1000
ELISA	1:5000

Protocols：

Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes.
基因功能參考文獻：
1. Our findings suggested that ZBP-89 and Sp1 overexpression induced Bak expression in a genetic manner. Increased Bak level was associated with poor patient survival, whereas high level of Sp1 is a beneficial factor for patient survival. PMID: 29653560
2. The results indicate that the association with chr5p15.33-Region 2 may be explained by rs36115365, a variant influencing TERT expression via ZNF148 in a manner consistent with elevated TERT in carriers of the C allele. PMID: 28447668
3. ZNF148 as a gene involved in a newly described intellectual disability syndrome with a recurrent phenotype and postulate that the ZNF148 is a hitherto unrecognized but crucial transcription factor in the development of the corpus callosum. PMID: 27964749
4. A larger role ZBP-89 plays in gene regulation during inflammation.ZBP-89 regulates of MMP-1 expression.ZBP-89 and NF-kappaB appear to bind cooperatively on both promoters. PMID: 26891870
5. ZBP-89 attenuates HDAC3 by increasing IkappaB degradation, dependent on Pin1 but independent of NF-Kappab PMID: 25623232
6. zinc-binding protein-89 upregulates the expression of Bak by targeting multiple components of the epigenetic pathway in hepatocellular carcinoma. PMID: 23954442
7. lower expression of ZNF148 in colorectal cancer was significantly associated with worse clinicopathologic variables, including lymph node metastases, poor differentiation, and a higher rate of disease recurrence PMID: 23576061
8. this study provides vigorous evidence that ZBP-89 was significantly downregulated in clear cell renal cell carcinoma(CCRCC) and could be served as a promising biomarker for prediction of distal metastasis and prognosis of patient with CCRCC. PMID: 22982674
9. Colony formation was reduced dramatically in those hepatocellular carcinoma cell lines in which ZBP-89 overexpression was demonstrated; this appeared to correlate with increased apoptosis. PMID: 22372401
10. We found that the TP53-G245D variant but not TP53-R249S abrogated HDAC inhibitor p21 induction by binding to ZBP-89 and retaining it in the cytoplasm. PMID: 22214764
11. ZBP-89 is a regulator of Pdcd4 gene, binding to the basal promoter either alone or by interacting with Sp family members. PMID: 22111549
12. An activating role for ZBP-89 in human globin gene regulation and erythroid differentiation. PMID: 21828133
13. Alternative binding of ZBP89 or SP1 to the described region in the IRS2 promoter regulates neuronal IRS2 expression in a PI3K-dependent manner. PMID: 19875459
14. ZBP-89 is a repressor of the human beta 2-integrin CD11b gene during differentiation of monocytes into macrophages PMID: 12393719
15. ZBP-89 co-localized with p53 in the nucleus in about 67% (12 of 18) of all cases positive for the nuclear p53 protein, suggesting that ZBP-89 may play a role in the nuclear accumulation of the p53 protein in a subset recurrent hepatocellular carcinoma. PMID: 12759240
16. interaction of Stat3 and ZBP-89 may be crucial for overcoming the effects of the repressor ZBP-89, which suggests a novel mode for Stat3 gene activation. PMID: 14712222
17. ZBP-89-mediated apoptosis occurs via a p53-independent mechanism that requires JNK activation. PMID: 14963412
18. No association with psoriasis susceptibility PMID: 15175029
19. We conclude that ZBP-89 is a direct transcriptional activator of the enterocyte differentiation marker IAP. PMID: 16384873
20. Ectopic expression of ZBP-89 amplified the inhibitory effect of Fatty Acids on L2 -GH promoter activity. PMID: 16825291
21. ZBP-89 is an important co-activator of wild-type p53 and both proteins are negatively affected by functionally inactive p53 mutants. PMID: 16827139
22. Enhanced ZNF148 expression activates intestinal apoptosis, therefore ZNF148 is a therapeutic target to inhibit colon cancer development. PMID: 17019648
23. ataxia telangiectasia mutated protein phosphorylation of ZBP-89 contributes to Histone deacetylase inhibitors induction of p21(waf1) gene expression PMID: 17560543
24. sumoylation provides a reversible post-translational mechanism to control the activity of ZBP-89. PMID: 17940278
25. Transcription factors Sp3, ZBP-89 and NF-Y are capable of binding to the SOX18 promoter region. PMID: 18496767
26. both NF-kappaB and ZBP-89 bind to the site in vivo and provide evidence of competitive binding to MMP-3 promoter. PMID: 19275880
27. ZBP-89 greatly enhanced the killing effectiveness of 5-fluorouracil or staurosporine in hepatocellular carcinoma cells. PMID: 19362768
28. ZBP-89 iss able to restrain senescence in NCI-H460 human lung cancer cells, through epigenetically regulating p(16INK4a) expression. PMID: 19583777
29. ZBP-89 plays a role in erythroid and megakaryocytic development by cooperating with GATA-1 and/or FOG-1 in a developmental stage-specific manner. PMID: 18250154
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相關疾病：

Global developmental delay, absent or hypoplastic corpus callosum, and dysmorphic facies (GDACCF)
亞細胞定位：

Nucleus.
蛋白家族：

Krueppel C2H2-type zinc-finger protein family
數據庫鏈接：

HGNC: 12933

OMIM: 601897

KEGG: hsa:7707

STRING: 9606.ENSP00000353863

UniGene: Hs.592591

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