ZMYND8 Antibody
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中文名稱：ZMYND8兔多克隆抗體
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貨號：CSB-PA251537
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規格：￥2024
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圖片：
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Western blot analysis of extracts from 293 cells, using PKCB1 antibody.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) ZMYND8 Polyclonal antibody
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Uniprot No.：
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基因名：ZMYND8
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthesized peptide derived from internal of Human PKCB1.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：May act as a transcriptional corepressor for KDM5D. Required for KDM5D-mediated down-regulation of diverse metastasis-associated genes; the function seems to involve the recognition of the dual histone signature H3K4me1-H3K14ac. Suppresses prostate cancer cell invasion.
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基因功能參考文獻：
- Drebrin may regulate activities of epigenetic reader ZMYND8 via its cytoplasmic sequestration. PMID: 28966017
- The MYND domain of ZMYND8 directly interacts with PPPLPhi motifs in the NuRD subunit GATAD2A. PMID: 27732854
- Single domain disruptions destroy the functional network of interactions initiated by ZMYND8, impairing recruitment to sites of DNA damage. Our data establish a proof of principle that rigidity can be compensated by concomitant DNA and histone post-translational-modifications (PTMs) interactions, maintaining multivalent engagement of transient chromatin states. PMID: 27926874
- KDM5A demethylates H3K4 to allow ZMYND8-NuRD to operate within damaged chromatin to repair DNA double strand breaks. PMID: 28572115
- ZMYND8's PHD-Bromo cassette couples H3K4me1-H3K14ac with downregulation of metastasis-linked genes in prostate tumor cells. PMID: 27477906
- a dual histone reader ZMYND8 (zinc finger MYND (Myeloid, Nervy and DEAF-1)-type containing 8), was identified to be a novel target of all trans retinoic acid. PMID: 28232094
- Data suggest that epithelial-mesenchymal transition (EMT) is regulated by ZMYND8 (receptor for activated protein kinase C) which selectively activates gene promoters of CLDN1 (claudin 1) and CDH1 (E-cadherin) in breast cancer cells; thus, the presence of ZMYND8 could be implicated in maintaining epithelial phenotype of cells; ZMYND8 regulates invasion/migration of breast cancer cells. PMID: 28432260
- Findings reveal a RACK7/KDM5C-regulated, dynamic interchange between histone H3K4me1 and H3K4me3 at active enhancers, representing an additional layer of regulation of enhancer activity. Authors propose that RACK7/KDM5C functions as an enhancer "brake" to ensure appropriate enhancer activity, which, when compromised, could contribute to tumorigenesis. PMID: 27058665
- study identifies that ZMYND8 has CHD4-independent functions in regulating gene expression through its modified histone-binding ability. PMID: 26655721
- identified ZMYND8 (zinc finger and MYND [myeloid, Nervy, and DEAF-1] domain containing 8) as a novel DDR factor that recruits the nucleosome remodeling and histone deacetylation (NuRD) complex to damaged chromatin PMID: 25593309
- ZMYND8 induces vegfa mRNA expression selectively in prostate cancer xenografts. PMID: 25117453
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亞細胞定位：Nucleus. Cytoplasm.
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組織特異性：Expressed in all tissues examined with highest expression in brain, lung, pancreas, and placenta. Expressed in cutaneous T-cell lymphomas (CTCL).
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數據庫鏈接：
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