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中文名稱：ZMYND10兔多克隆抗體
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貨號：CSB-PA026511ESR2HU
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規格：￥440
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圖片：
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Western blot
All lanes: ZMYND10 antibody at 8μg/ml
Lane 1: A549 whole cell lysate
Lane 2: Mouse kidney tissue
Lane 3: Mouse skeletal muscle tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 51, 50 kDa
Observed band size: 51 kDa -
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA026511ESR2HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA026511ESR2HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) ZMYND10 Polyclonal antibody
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Uniprot No.：
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基因名：ZMYND10
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別名：ZMYND10 antibody; BLU antibody; LUCA12.4 antibody; Zinc finger MYND domain-containing protein 10 antibody; Protein BLu antibody
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宿主：Rabbit
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反應種屬：Human, Mouse
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免疫原：Recombinant Human Zinc finger MYND domain-containing protein 10 protein (201-440AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, WB, IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins.
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基因功能參考文獻：
- BLU suppressed tumor formation by strengthening the antitumor immunity. PMID: 28029652
- A novel frameshift mutation (c.367delC) in ZMYND10, unique for Slavic primary ciliary dyskinesia population (PCD), was found in homozygous state in two unrelated PCD patients. PMID: 26824761
- Data identified a novel functional BLU promoter that was regulated by Sp1. Furthermore, the hypermethylated -39 CpG in BLU proximal promoter directly reduced its binding with Sp1. PMID: 26043875
- Data show that the zinc finger MYND-type containing 10 protein BLU gene may be one of the key components of signaling networks controlling tumor microenvironment and angiogenesis. PMID: 25347745
- Mutations in ZMYND10 cause primary ciliary dyskinesia. PMID: 23891471
- Methylation of BLU could be a potential prognostic biomarker for advanced ovarian serous carcinoma PMID: 23329649
- Data indicate that BLU could suppress the growth of ovarian carcinoma cells through down-regulation of Bcl-2 protein. PMID: 23628417
- these data indicated that methylation of the BLU promoter region is an early event during hepatocellular carcinoma development. PMID: 22766745
- The N-terminal of BLU was observed to interact with the C-terminal of SMEK1, a regulatory subunit of protein phosphatase 4. Furthermore, we determined the binding domains that are required for interaction between BLU and sMEK1. The N-terminal of BLU was observed to interact with the C-terminal of sMEK1. PMID: 22349239
- BLU may play a substantial role in the development and etiology of myelodysplastic syndrome. PMID: 22246278
- A significant correlation between BLU methylation and loss of expression of BLU was observed in gastric, colorectal and pancreatic cancers. PMID: 20394502
- These data suggest a significant role for epigenetic inactivation of BLU in the pathogenesis of common human cancers and that methylation inactivation of BLU occurs independent of RASSF1A in SCLC and neuroblastoma tumours. PMID: 12629521
- BLU may be one of the critical tumor suppressor genes on chromosome 3p21.3 involved in the development of nasopharyngeal carcinoma PMID: 12794757
- BLU, a candidate tumor suppressor gene, located at the commonly deleted region 3p21.3, is an E2F-regulated, stress-responsive gene and inactivated by both epigenetic and genetic mechanisms in nasopharyngeal carcinoma. PMID: 15122337
- Smoking under age 18 is an independent risk for BLU hypermethylation, thus identifying a molecular alteration related to the epidemiologic effect of teenage smoking as a lung cancer risk. PMID: 15540210
- ninety-two percent of glioma tumor samples were methylated for RASSF1A, 30%-57% for BLU and 47% for MGMT, suggesting promoter methylation of these genes to be a common event in glioma tumorigenesis PMID: 18616639
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相關疾病：Ciliary dyskinesia, primary, 22 (CILD22)
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亞細胞定位：Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Apical cell membrane. Dynein axonemal particle.
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蛋白家族：ZMYND10 family
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數據庫鏈接：
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