ZMAT3 Antibody

說明書

中文名稱：

ZMAT3兔多克隆抗體
貨號：

CSB-PA026499GA01HU
規格：

￥3,900
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q9HA38
基因名：

ZMAT3
別名：

FLJ12296 antibody; FLJ31683 antibody; MGC10613 antibody; OTTHUMP00000211906 antibody; OTTHUMP00000211907 antibody; p53 activated gene 608 antibody; p53 inducible zinc finger protein antibody; p53 target zinc finger protein antibody; p53-activated gene 608 protein antibody; PAG 608 antibody; WIG 1 antibody; WIG 1/PAG608 protein antibody; WIG1 antibody; WIG1/PAG608 protein antibody; Wildtype p53-induced gene antibody; Zinc finger matrin type 3 antibody; Zinc finger matrin-type protein 3 antibody; Zinc finger protein WIG 1 antibody; Zinc finger protein WIG-1 antibody; Zinc finger protein WIG1 antibody; ZMAT 3 antibody; Zmat3 antibody; ZMAT3_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human ZMAT3
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Acts as a bona fide target gene of p53/TP53. May play a role in the TP53-dependent growth regulatory pathway. May contribute to TP53-mediated apoptosis by regulation of TP53 expression and translocation to the nucleus and nucleolus.
基因功能參考文獻：
1. WIG1 governs the miRNA-dependent and the miRNA-independent recruitment of AGO2 to lower the stability of and suppress the translation of ACOT7 mRNA. PMID: 28472401
2. we propose that Wig1, a key p53 downstream molecule in HD condition, play an important role in stabilizing mutant Htt mRNA and thereby accelerating HD pathology in the mHtt-p53-Wig1 positive feedback manner PMID: 27206983
3. expression of the p53 target Wig-1 is associated with HPV status and patient survival in cervical carcinoma PMID: 25379706
4. Results suggest a role of Wig-1 as a survival factor that directs the p53 stress response toward cell cycle arrest rather than apoptosis through the regulation of FAS and 14-3-3sigma mRNA levels. PMID: 24469038
5. PSF and MATR3 are cellular host factors that bind viral RNA and promote Rev activity. PMID: 23158102
6. The data indicated a novel role for Wig1 in RNA-induced silencing complex target accessibility, which is a key step in RNA-mediated gene silencing. Fine tuning of p21 levels by Wig1 was essential for the prevention of cellular senescence. PMID: 23085987
7. Wig-1 knockdown causes a dramatic inhibition of N-Myc expression and triggers differentiation in neuroblastoma cells carrying amplified N-Myc. PMID: 22513872
8. WIG-1 might be involved in the zinc-induced cell cycle arrest and apoptosis of human esophageal squamous cell carcinoma cells PMID: 21559779
9. WIG-1 might be a novel modifier in esophageal carcinogenesis, and the WIG-1 MAb should be useful in further study of the mechanism in WIG-1-related physiological reactions. PMID: 21050045
10. The cellular distribution of the nuclear matrix protein matrin 3 is altered by novel phosphorylation induced by the alphaherpesvirus US3 kinase family. PMID: 20962082
11. Results demonstrate that human Wig-1 can bind different types of double-stranded RNAs (dsRNAs), including dsRNAs resembling small interfering RNAs and microRNAs, and indicate that dsRNA binding has a role in Wig-1-mediated regulation of cell growth. PMID: 16844115
12. Wig-1-binding proteins, hnRNP A2/B1 and RNA Helicase A, both of which are involved in RNA processing, were identified. PMID: 18519039
13. Data demonstrated a direct interaction between Dicer and Wig-1 and both may play a common role in dsRNA-related gene regulation. PMID: 19127773
14. the p53 target Wig-1 is a previously undescribed AU-rich element-regulating protein that acts as a positive feedback regulator of p53, with implications both for the steady-state levels of p53 and for the p53 stress response PMID: 19805223
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亞細胞定位：

Nucleus. Nucleus, nucleolus.
組織特異性：

Highly expressed in adult brain, and moderately in adult kidney and testis. Not detected in fetal brain, heart, pancreas, adrenal gland, liver or small intestine.
數據庫鏈接：

HGNC: 29983

OMIM: 606452

KEGG: hsa:64393

STRING: 9606.ENSP00000311221

UniGene: Hs.371609

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