ZFYVE26 Antibody

中文名稱：

ZFYVE26兔多克隆抗體
貨號(hào)：

CSB-PA734654LA01HU
規(guī)格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA734654LA01HU at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA734654LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產(chǎn)品詳情
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產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) ZFYVE26 Polyclonal antibody
Uniprot No.：

Q68DK2
基因名：

ZFYVE26
別名：

DKFZp686F19106 antibody; DKFZp781H1112 antibody; FYVE domain-containing centrosomal protein antibody; FYVE-CENT antibody; KIAA0321 antibody; Spastic paraplegia 15 (complicated autosomal recessive) antibody; Spastizin antibody; SPG15 antibody; ZFY26_HUMAN antibody; ZFYVE 26 antibody; ZFYVE26 antibody; Zinc finger FYVE domain containing 26 antibody; Zinc finger FYVE domain containing protein 26 antibody; Zinc finger FYVE domain-containing protein 26 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Zinc finger FYVE domain-containing protein 26 protein (2306-2473AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁面中的產(chǎn)品，ZFYVE26 Antibody (CSB-PA734654LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于ZFYVE26 Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號(hào)	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA734654LB01HU	ZFYVE26 Antibody, HRP conjugated	ELISA
FITC	CSB-PA734654LC01HU	ZFYVE26 Antibody, FITC conjugated
Biotin	CSB-PA734654LD01HU	ZFYVE26 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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功能：

Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair.
基因功能參考文獻(xiàn)：
1. Our protocol showed high specificity and sensitivity for homozygosity detection and facilitated the identification of novel mutations in GAN, GBA2, and ZFYVE26 in four families affected by hereditary spastic paraplegia or Charcot-Marie-Tooth disease PMID: 26492578
2. spastizin and spatacsin were essential components for the initiation of lysosomal tubulation. Together, these results link dysfunction of the autophagy/lysosomal biogenesis machinery to neurodegeneration. PMID: 25365221
3. ZFYVE26 is a key determinant of autophagosome maturation PMID: 24284334
4. spg15 should be search for in the case of juvenile levodopa reponsive parkinsonism PMID: 24366652
5. We propose AP-5, SPG15, SPG11 form a coat-like complex, with AP-5 involved in protein sorting, SPG15 facilitating docking of the coat onto membranes by interacting with PI3P via its FYVE domain, and SPG11 (possibly together with SPG15) forming a scaffold. PMID: 23825025
6. spastizin interacts with the autophagy related Beclin 1-UVRAG-Rubicon multiprotein complex and is required for autophagosome maturation. PMID: 24030950
7. SPG15 was strongly expressed in cortical and spinal motor neurons and in embryos. It partially co-localized with multiple organelles, particularly with protein-trafficking vesicles, endoplasmic reticulum, microtubules and the mitochondria surface. PMID: 21545838
8. Findings suggest a positive feedback loop for recruitment of FYVE-CENT and Beclin 1 to the intercellular bridge during cytokinesis, and reveal a novel potential tumor suppressor mechanism for Beclin 1. PMID: 21455500
9. PtdIns(3)P production is essential for proper cytokinesis. PtdIns(3)P-binding centrosomal protein FYVE-CENT and TTC19 control cytokinesis through their translocation from the centrosome to the midbody mediated by the kinesin protein KIF13A. PMID: 20208530
10. phenotypic heterogeneity of SPG15 in which mental retardation or cognitive deterioration, but not all other signs of Kjellin syndrome, are associated with hereditary spastic paraplegia and significantly reduces the SPG15 locus PMID: 17661097
11. Autosomal recessive HSP-TCC is a frequent subtype of complicated HSP in Tunisia and is clinically and genetically heterogeneous. SPG11 and SPG15 are the major loci for this entity. PMID: 18332254
12. Refinement of SPG15 to a 2.64 Mb genetic interval on chromosome 14q23.3-q24.2 and the identification of ZFYVE26 was reported in families with complicated autosomal-recessive spastic paraplegia, including Kjellin syndrome. PMID: 18394578
13. Of patients with hereditary spastic paraplegia-thin corpus callosum, the largest analyzed so far, SPG15 was the second most frequent form (11.5%) after SPG11. PMID: 19805727
14. phenotype and mutation frequency compared with SPG11 in complicated hereditary spastic paraplegia PMID: 19917823
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相關(guān)疾病：

Spastic paraplegia 15, autosomal recessive (SPG15)
亞細(xì)胞定位：

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Note=Localizes to the centrosome during all stages of the cell cycle. Recruited to the midbody during cytokinesis by KIF13A.
組織特異性：

Strongest expression in the adrenal gland, bone marrow, adult brain, fetal brain, lung, placenta, prostate, skeletal muscle, testis, thymus, and retina. Intermediate levels are detected in other structures, including the spinal cord.
數(shù)據(jù)庫鏈接：

HGNC: 20761

OMIM: 270700

KEGG: hsa:23503

STRING: 9606.ENSP00000251119

UniGene: Hs.98041

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