ZFP57 Antibody

中文名稱：

ZFP57兔多克隆抗體
貨號：

CSB-PA865138LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: HepG2 whole cell lysate, 293 whole cell lysate, Mouse brain tissue
All lanes: ZFP57 antibody at 13.6µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 52, 60, 62 kDa
Observed band size: 52 kDa
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) ZFP57 Polyclonal antibody
Uniprot No.：

Q9NU63
基因名：

ZFP57
別名：

ZFP57 antibody; C6orf40 antibody; ZNF698 antibody; Zinc finger protein 57 homolog antibody; Zfp-57 antibody; Zinc finger protein 698 antibody
宿主：

Rabbit
反應種屬：

Human, Mouse
免疫原：

Recombinant Human Zinc finger protein 57 homolog protein (183-295AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，ZFP57 Antibody (CSB-PA865138LA01HU)，的標記方式是Non-conjugated。對于ZFP57 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA865138LB01HU	ZFP57 Antibody, HRP conjugated	ELISA
FITC	CSB-PA865138LC01HU	ZFP57 Antibody, FITC conjugated
Biotin	CSB-PA865138LD01HU	ZFP57 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs). Acts together with ZNF445, but ZNF445 seems to be the major factor in human early embryonic imprinting maintenance. In contrast, in mice, ZFP57 plays the predominant role in imprinting maintenance. Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells. Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element.
基因功能參考文獻：
1. transient neonatal diabetes type 1 is associated with ZFP57 mutations PMID: 27075368
2. ZFP57 regulates the expression of insulin-like growth factor 2 (IGF2), which has a critical role in ZFP57-induced anchorage-independent growth PMID: 24469060
3. High grade glioblastoma is associated with increased level of ZFP57, a protein involved in gene imprinting, and aberrant expression of CPT1A and CPT1C. PMID: 24618825
4. These data identify ZFP57 as a candidate gene underlying reported MHC disease associations, notably for putative regulatory variants associated with cancer and HIV-1. PMID: 24193346
5. Mouse and human ZFP57 are orthologs despite relatively low sequence identity. PMID: 24135613
6. ZFP57 vZFP57 vZFP57 PMID: 23748067
7. hZFP57 mutations and hypomethylation of the TNDM1 imprinted control region both associated with Transient Neonatal Diabetes Mellitus type 1 result in loss of hZFP57 binding to the TNDM1 locus. PMID: 23499433
8. no evidence for ZFP57 alterations as a major cause in sporadic Beckwith-Wiedemann Syndrome cases PMID: 21863059
9. this study does not provide evidence that ZFP57 mutations are the cause of 11p15-hypomethylation in Silver-Russell syndrome (SRS) patients and contribute to the aetiology of SRS PMID: 19632365
10. Study reports mutations in ZFP57, which encodes a zinc-finger transcription factor expressed in early development, in seven pedigrees with a shared pattern of mosaic hypomethylation and a conserved range of clinical features. PMID: 18622393
11. Observational study of gene-disease association. (HuGE Navigator) PMID: 19851445
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相關疾病：

Transient neonatal diabetes mellitus 1 (TNDM1)
亞細胞定位：

Nucleus.
蛋白家族：

Krueppel C2H2-type zinc-finger protein family, ZFP57 subfamily
數據庫鏈接：

HGNC: 18791

OMIM: 601410

KEGG: hsa:346171

UniGene: Hs.156326

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