ZC3H14 Antibody

中文名稱：

ZC3H14兔多克隆抗體
貨號：

CSB-PA740793LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: A549 whole cell lysate, 293T whole cell lysate, SH-SY5Y whole cell lysate
All lanes: ZC3H14 antibody at 3.9µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 83, 66, 65, 81, 35, 33, 62, 67 kDa
Observed band size: 83 kDa

IHC image of CSB-PA740793LA01HU diluted at 1:400 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA740793LA01HU diluted at 1:400 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) ZC3H14 Polyclonal antibody
Uniprot No.：

Q6PJT7
基因名：

ZC3H14
別名：

FLJ11806 antibody; Mammalian suppressor of tau pathology-2 antibody; MGC26892 antibody; MSUT-2 antibody; Nuclear protein UKp68 antibody; NY REN 37 antibody; NYREN 37 antibody; Renal carcinoma antigen NY REN 37 antibody; Renal carcinoma antigen NY-REN-37 antibody; Renal carcinoma antigen NYREN 37 antibody; suppressor of tau 2, C. elegans, homolog of antibody; SUT2 antibody; UKp68 antibody; ZC3H14 antibody; ZC3HE_HUMAN antibody; Zinc finger CCCH domain-containing protein 14 antibody; Zinc finger CCCH type containing 14 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Zinc finger CCCH domain-containing protein 14 protein (176-306AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，ZC3H14 Antibody (CSB-PA740793LA01HU)，的標記方式是Non-conjugated。對于ZC3H14 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA740793LB01HU	ZC3H14 Antibody, HRP conjugated	ELISA
FITC	CSB-PA740793LC01HU	ZC3H14 Antibody, FITC conjugated
Biotin	CSB-PA740793LD01HU	ZC3H14 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:200-1:500

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides.
基因功能參考文獻：
1. ATP5G1 turnover increases upon depletion of ZC3H14, double knockdown of ZC3H14 and the nonsense-mediated decay factor, UPF1, rescues ATP5G1 transcript levels. Furthermore, fractionation reveals an increase in the amount of ATP5G1 pre-mRNA that reaches the cytoplasm when ZC3H14 is depleted and that ZC3H14 binds to ATP5G1 pre-mRNA in the nucleus. PMID: 27563065
2. we show here that human ZC3H14 can functionally substitute for dNab2 in fly neurons and can rescue defects in development and locomotion that are present in dNab2 null flies PMID: 24671764
3. report a intellectual disability disease locus on chromosome 14q31.3 corresponding to mutation of the ZC3H14 gene that encodes a conserved polyadenosine RNA binding protein PMID: 21734151
4. MSUT2 levels may influence neuronal vulnerability to tau toxicity and aggregation. PMID: 21355046
5. New neuroprotective strategies targeting MSUT-2 that may be effective in modulating tau neurotoxicity in human tauopathy disorders. PMID: 20658987
6. these proteins are members of an evolutionarily conserved family of poly(A) RNA binding proteins PMID: 17630287
7. multiple transcripts encoding several ZC3H14 isoforms exist in vivo PMID: 19303045
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相關疾病：

Mental retardation, autosomal recessive 56 (MRT56)
亞細胞定位：

Nucleus speckle.; [Isoform 1]: Nucleus speckle.; [Isoform 3]: Nucleus speckle.; [Isoform 6]: Cytoplasm.
蛋白家族：

ZC3H14 family
組織特異性：

Isoform 1 and isoform 6 are expressed in fetal and adult brain. Isoform 1 and isoform 6 are expressed in fetal and adult temporal lobe.
數據庫鏈接：

HGNC: 20509

OMIM: 613279

KEGG: hsa:79882

STRING: 9606.ENSP00000251038

UniGene: Hs.684046

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