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貨期:
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用途:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1.
基因功能參考文獻:
The level of miR-4262 was found to be significantly decreased in CC tissues and cell lines. Moreover, decreased expression of miR-4262 was closely related to increased expression of Kaiso (ZBTB33). PMID: 28800784
extracellular microenvironment signals regulate RhoH and Kaiso to modulate actin-cytoskeleton structure and transcriptional activity during T cell migration PMID: 27574848
Kaiso silencing had similar effects as miR-181a overexpression in glioma cells, whereas overexpression of Kaiso in glioma cells partially reversed the inhibitory effects of the miR-181a mimic. PMID: 30036882
data show that Kaiso favors an mCpG over a CpG site by 2 orders of magnitude in affinity and that an important component of this effect is the presence of hydrophobic and CH...O contacts involving E535. PMID: 29546986
High levels of nuclear Kaiso expression were detected in patients with a higher degree of African heritage compared to their Caucasian counterparts, suggesting a role for Kaiso in triple-negative breast cancer racial disparity. PMID: 28887687
Kaiso promotes Jagged-1 expression, which may have implications in Notch-mediated colon cancer progression PMID: 28637464
the pathological features of the metastatic activity of parental (Kaisopositive) versus Kaisodepleted MDA-231 cells, are reported. PMID: 28880889
Suggest a role for Kaiso in the progression of pancreatic ductal adenocarcinomas, involving the epithelial mesenchymal transformation markers, E-cadherin and Zeb1. PMID: 27424525
a novel mechanism by which ZBTB33 mediates the cyclin D1/cyclin E1/RB1/E2F pathway, controlling passage through the G1 restriction point and accelerating cancer cell proliferation. PMID: 27694442
Kaiso high expression correlated with invasion of prostate cancer. PMID: 26734997
Results show that Kaiso binding to unmethylated Kaiso binding site in the human ICR1 is necessary for ICR1 methylation maintenance and affects transcription rates of the lncRNA H19. PMID: 27152123
Kaiso modulates HIF1A gene expression by binding to the methylated HIF1A promoter in a region proximal to the autoregulatory HIF-1 binding site, primarily during hypoxia. PMID: 26514431
NF-kappaB response element, located close to the p53RE#1, mediates APAF1 transcriptional repression by affecting interaction between KAISO and p53 PMID: 26183023
KAISO is a regulator of p53-mediated transcription of CDKN1A and apoptotic genes PMID: 25288747
Data indicate that Kaiso protein participates in the regulation of beta-catenin mRNA expression by interacting with p120-catenin in the lung cancer cell lines. PMID: 24498333
Nuclear localization of Kaiso promotes the poorly differentiated phenotype and EMT in infiltrating ductal carcinomas. PMID: 24570268
The optimized knockdown with p120 and Kaiso siRNAs further expands the size of HCEC monolayers without endothelial mesenchymal transition (EMT) via selective activation of p120/Kaiso signaling that requires the RhoA-ROCK-noncanonical BMP-NFkB signaling. PMID: 24474278
Transcription factor Kaiso does not interact with hydroxymethylated DNA within CTGCNA sequence context PMID: 23888785
presence of MTG16 in this complex, and its contributions to transcriptional repression both required Kaiso binding to its binding site on DNA, establishing MTG16-Kaiso binding as functionally relevant in Kaiso-dependent transcriptional repression PMID: 23251453
Kaiso represses the cell cycle gene cyclin D1 via sequence-specific and methyl-CpG-dependent mechanism. PMID: 23226276
These findings establish a defined oncogenic role of Kaiso in promoting the progression of prostate cancer. PMID: 22974583
High cytoplasmic kaiso expression is associated with thymoma. PMID: 22833212
nuclear Kaiso is common in clinically aggressive ductal breast cancer, while cytoplasmic Kaiso and a p120-mediated relief of Kaiso-dependent transcriptional repression characterize invasive lobular carcinoma (ILC). PMID: 22662240
Molecular basis for recognition of methylated and specific DNA sequences by the zinc finger protein Kaiso PMID: 22949637
Selective activation of p120ctn-Kaiso signaling to unlock contact inhibition of ARPE-19 cells without epithelial-mesenchymal transition. PMID: 22590627
Data show that Kaiso requires all three zinc fingers plus adjacent protein regions for DNA recognition. PMID: 22300642
Results suggest that p120ctn isoforms 1 and 3 up-regulate cyclin D1, and thereby cyclin E, resulting in the promotion of cell proliferation and cell cycle progression in lung cancer cells. PMID: 22276175
when released from E-cadherin by Wnt3a-stimulated phosphorylation, p120-catenin controls the activity of Kaiso, enhancing its binding to repressed promoters and relieving its inhibition of the beta-catenin-Tcf-4 transcriptional complex. PMID: 21670201
Increased delta-catenin expression is critical for maintenance of the malignant phenotype of lung cancer, making delta-catenin a candidate target protein for future cancer therapeutics. PMID: 21070476
In endothelial cells, p120ctn has a transcription repression function through regulation of Kaiso, possibly as a cofactor with the transcription factor. PMID: 20382170
Data strongly imply that Kaiso's function as a transcriptional regulator might be linked to the control of the cell cycle and to cell proliferation in cancer. PMID: 20169156
Bifunctional role of domain zinc fingers of methyl-DNA-binding protein Kaiso PMID: 20586187
differential expression of p120(ctn) and Kaiso mRNA was observed in human coronary artery endothelial cells depending on how laminar shear stress was applied in relation to the wounding process PMID: 14699141
Kaiso translocates to the nucleus to regulate transcription of genes with diverse roles in cell growth and development PMID: 15564377
Data imply an unexpected influence of the microenvironment on Kaiso expression and localizationin colorectal adenocarcinoma. PMID: 15781635
Kaiso associates with the matrilysin promoter in vivo. PMID: 15817151
KAISO binds specifically to the methylated, but not the unmethylated, sequence in the first exon of the tyrosine hydroxylase [TH]gene and thus may play an important role in modulating human TH gene expresison. PMID: 15953356
the Kaiso-CTCF interaction negatively regulates CTCF insulator activity PMID: 16230345
Our study suggests that this gene is not implicated in the RTT molecular pathogenesis PMID: 16530985
p120 and Kaiso regulate Helicobacter pylori-induced expression of matrix metalloproteinase-7 PMID: 18653469
Kaiso represses methylated tumor suppressor genes and can bind in a methylation-dependent manner to the CDKN2A in human colon cancer cell lines. Kaiso depletion induced tumor suppressor gene expression without affecting DNA methylation levels. PMID: 18794111
Kaiso plays some specific role in centrosome assembly and function, which is not restricted to mitosis PMID: 19502788
Data suggest cytoplasmic Kaiso expression is associated with poor prognosis of NSCLC and various subcellular localizations of Kaiso may play differential biological roles in NSCLC. PMID: 19508730
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亞細胞定位:
Nucleus. Cytoplasm. Note=Also cytoplasmic in cells grown at high densities.