XPNPEP3 Antibody
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中文名稱：XPNPEP3兔多克隆抗體
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貨號：CSB-PA026220GA01HU
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規(guī)格：￥3,900
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：XPNPEP3
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別名：Aminopeptidase P3 antibody; APP3 antibody; NPHPL1 antibody; OTTHUMP00000199806 antibody; Probable Xaa Pro aminopeptidase 3 antibody; Probable Xaa-Pro aminopeptidase 3 antibody; X Pro aminopeptidase 3 antibody; X prolyl aminopeptidase (aminopeptidase P) 3 antibody; X-Pro aminopeptidase 3 antibody; XPNPEP3 antibody; XPP3_HUMAN antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Human XPNPEP3
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB,IHC
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Leu-Pro-Ala. Also shows low activity towards peptides with Ala or Ser at the P1 position.; Promotes TNFRSF1B-mediated phosphorylation of MAPK8/JNK1 and MAPK9/JNK2, suggesting a function as an adapter protein for TNFRSF1B; the effect is independent of XPNPEP3 peptidase activity. May inhibit apoptotic cell death induced via TNF-TNFRSF1B signaling.
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基因功能參考文獻(xiàn)：
- results therefore suggest XPNPEP3 to be a transcriptional target of Wnt/beta-catenin pathway with particular significance for CRC PMID: 29383790
- Data suggest that human XPNPEP3, Ashbya gossypii Icp55, and Fusarium graminearum Icp55 exhibit structural and functional properties of genuine Xaa-Pro specific aminopeptidases; these enzymes appear to function in the previously observed mitochondrial role of Icp55 in processing of Nfs1 (mitochondrial cysteine desulfurase) substrate. [Icp55 = intermediate-cleavage metalloexopeptidases 55] PMID: 28476889
- The findings reveal that APP3m is a new member of the TNF-TNFR2 signaling complex and characterize an APP3-mediated TNFR2 signal transduction mechanism that induces activation of JNK1 and JNK2. PMID: 25609706
- Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy. PMID: 20179356
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相關(guān)疾病：Nephronophthisis-like nephropathy 1 (NPHPL1)
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亞細(xì)胞定位：[Isoform 1]: Mitochondrion. Cytoplasm.; [Isoform 2]: Cytoplasm.
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蛋白家族：Peptidase M24B family
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組織特異性：Isoform 1 and isoform 2 are widely expressed, with isoform 1 being more abundant.
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數(shù)據(jù)庫鏈接：
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