XCL1 Antibody
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中文名稱：XCL1兔多克隆抗體
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貨號：CSB-PA026186ESR1HU
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規格：￥440
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) XCL1 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：ATAC antibody; C motif chemokine 1 antibody; Chemokine (C motif) ligand 1 antibody; Chemokine C Motif Ligand 1 antibody; Cytokine SCM-1 antibody; LPTN antibody; LTN antibody; Lymphotactin antibody; Lymphotaxin antibody; SCM 1 alpha antibody; SCM 1 antibody; SCM 1a antibody; SCM-1-alpha antibody; SCM1 antibody; SCM1A antibody; SCYC1 antibody; Single cysteine motif 1a antibody; Small inducible cytokine C1 antibody; Small Inducible Cytokine Subfamily C Member 1 antibody; Small inducible cytokine subfamily C, member 1 (lymphotactin) antibody; Small-inducible cytokine C1 antibody; X-C motif chemokine ligand 1 antibody; XC chemokine ligand 1 antibody; Xcl1 antibody; XCL1_HUMAN antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Lymphotactin protein (22-114AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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靶點詳情
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功能：Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment.
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基因功能參考文獻：
- higher serum XCL1 levels at diagnosis and their progressive decline throughout chemotherapy could be correlated with higher survival. PMID: 29027574
- This study defines a Glycosaminoglycan binding surface on XCL1 dimer that includes residues that are important for HIV-1 inhibition. PMID: 26836755
- Electrostatics and Hydrophobic Effects in the Metamorphic Protein Human Lymphotactin PMID: 26134347
- XCL1 acts via direct interaction with the external viral envelope glycoprotein, gp120, to block HIV-1 infection PMID: 26085164
- analysis of XCL1 and XCL2, members of the C-chemokine subfamily, in the immune system PMID: 25497737
- XCL1 displays antimicrobial activity against E. coli and S. aureus. PMID: 12949249
- XCL1-mediated inhibition is associated with direct interaction of the chemokine with the HIV-1 envelope. PMID: 24385911
- In native annulus fibrosus tissue homeostasis and repair, CXCR3 is evident, whereas XCL1 could not be detected. PMID: 21270681
- The expression patterns of XCR1 and XCL1 were conserved in human and mice blood cells, including certain dendritic cell subsets. PMID: 20541533
- Data indicated increased expression of XCL1 in CD4+ and CD8+ T cells in Wegener's granulomatosis (WG), and suggest that XCL1 might be a key modulator of T cell recruitment in WG. PMID: 19797511
- NMR spectra of human lymphotactin (hLtn), obtained under various solution conditions, have revealed that the protein undergoes a major conformational rearrangement dependent on temperature and salt concentration. PMID: 11889129
- lymphotactin, as well as MCP-1, may contribute to leukocyte infiltration and disease progression in IgA nephropathy. PMID: 12053063
- Lptn might be a key modulator for T cell trafficking in the pathogenesis of rheumatoid arthritis PMID: 12847680
- In humans XCL1 expression is mainly a property of CD8+ T cells; the contribution to its synthesis by different T cell receptor alpha beta-expressing T cell subsets, namely CD4+ lymphocytes, is negligible. PMID: 14568926
- lymphotactin utilizes highly specific glycosaminoglycan-binding sites PMID: 14707146
- XCL1 activation is positively correlated with HIV-1 Tat expression in human U87.MG astrocytes in vitro. PMID: 14734774
- description of a lymphotactin-producing monoclonal T-cell lymphoproliferative disorder with extreme lymphocytopenia and progressive leukoencephalopathy [case report] PMID: 16923584
- The monocyte-derived dendritic cells can express Lptn mRNA in a maturation-dependent manner. PMID: 17077010
- Elevated serum lymphotactin levels correlate with relatively milder manifestations in diffuse cutaneous systemic sclerosis (dSSc), especially lower severity of lung involvement, suggesting that lymphotactin may play a role in the development of dSSc. PMID: 18322986
- functional repertoire and regulation of a single naturally occurring amino acid sequence can be expanded by access to a set of highly dissimilar native-state structures PMID: 18364395
- XCL1 enhances regulatory activities of CD4+ CD25(high) CD127(low/-) T cells in human allergic asthma PMID: 18832695
- ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein PMID: 18838386
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亞細胞定位：Secreted.
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蛋白家族：Intercrine gamma family
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組織特異性：Highest level in spleen, lower in peripheral leukocytes and very low levels in lung, colon and small intestine.
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數據庫鏈接：
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