WWP2 Antibody

中文名稱：

WWP2兔多克隆抗體
貨號：

CSB-PA026168LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA026168LA01HU at dilution of 1:100
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) WWP2 Polyclonal antibody
Uniprot No.：

O00308
基因名：

WWP2
別名：

WWP2NEDD4-like E3 ubiquitin-protein ligase WWP2 antibody; EC 2.3.2.26 antibody; Atrophin-1-interacting protein 2 antibody; AIP2 antibody; HECT-type E3 ubiquitin transferase WWP2 antibody; WW domain-containing protein 2 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human NEDD4-like E3 ubiquitin-protein ligase WWP2 protein (145-367AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，WWP2 Antibody (CSB-PA026168LA01HU)，的標記方式是Non-conjugated。對于WWP2 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA026168LB01HU	WWP2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA026168LC01HU	WWP2 Antibody, FITC conjugated
Biotin	CSB-PA026168LD01HU	WWP2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.
基因功能參考文獻：
1. The present study suggested that miR32 may effectively inhibit WWP2 expression in human amniotic epithelial stem cells and promote Oct4 overexpression to maintain their pluripotency. PMID: 29393344
2. Our study suggests that WWP2 may play a role in the genesis and development of glioma; it may be a potential biomarker to predict pathological grade and tumor recurrence in patients with glioma. PMID: 29237971
3. SNP rs62051384, located within WWP2, showed an association with plantar fascial disorders at genome-wide significance (p<5x10(-8)) with small effects (odds ratios=0.93 and 1.07 per allele, respectively). PMID: 29534260
4. Describe an autoinhibitory mechanism for WWP2 ubiquitin ligase involving a linker-HECT domain interaction. This intramolecular interaction traps the HECT enzyme in its inactive state and can be relieved by linker phosphorylation. PMID: 28475870
5. results provide evidence that WWP2 serves as a positive regulator of osteogenesis by augmenting RUNX2 transactivation in a non-proteolytic mono-ubiquitination manner. PMID: 28500134
6. Data suggest that elevated expression of WW domain containing E3 ubiquitin protein ligase 2 (WWP2) may play a role in facilitating the development of lung adenocarcinoma. PMID: 27462019
7. we demonstrate that WWP2 promotes cell adhesion, invasion, and migration in liver cancer by upregulating CXCR3 and CCR5 expression associated with the chemokine signaling pathway. PMID: 26662306
8. WWP2 may represent a novel diagnostic marker and molecular therapeutic target for liver cancer. PMID: 26783238
9. majority of ovarian carcinomas harbored homozygous or heterozygous deletions in WWP2 locus, and there was an inverse correlation in the expression levels between WWP2 and Notch3 in ovarian carcinomas PMID: 25356737
10. Results identify WWP2 as a novel p73-associated protein that ubiquitinates and degrades p73. PMID: 25071155
11. Wwp2 acts as a ubiquitin ligase of SRG3. PMID: 24365151
12. WWP2-N is downregulated in stage IIIC melanoma and up-regulated in stage II/III prostate cancer, and WWP2-FL and WWP2-C overexpression is associated with early-stage breast cancer. PMID: 23938591
13. Koala retrovirus Gag PPPY L-domain interacts with the WW domain(s) of WWP2 and progeny virions are released from cells by utilizing the multivesicular body sorting pathway. PMID: 23651516
14. WWP2 controls cellular apoptosis and is required for tumorigenicity of cells PMID: 21532586
15. Data show that the WWP2-N isoform interacts with Smad2 and Smad3, whereas WWP2-C interacts only with Smad7. PMID: 21258410
16. expression, binding, and functional data all suggest that WWP2 is a candidate to regulate ENaC-mediated Na(+) transport in epithelia PMID: 12167593
17. First demonstration of ubiquitin-protein ligase WWP2 from human lung cDNA library recruited by penton base proteins of adenovirus serotypes Ad2 and Ad3 in vitro and in vivo. PMID: 12450395
18. Data show that WWP2 and Nedd4-2 both bind to the cardiac sodium channel Na(v)1.5, but only Nedd4-2 robustly ubiquitinated and downregulated Na(v)1.5. PMID: 15548568
19. cIAP1 and cIAP2 promote cancer cell survival by functioning as E3 ubiquitin ligases that maintain constitutive ubiquitination of the RIP1 adaptor protein. PMID: 18570872
20. The WWP2 protein is an important regulator for maintaining a proper POU5F1 protein level in human Embryonic Stem Cells. PMID: 19274063
21. AIP2 regulates activation-induced T-cell death by suppressing EGR2-mediated FasL expression via the ubiquitin pathway PMID: 19651900
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亞細胞定位：

Nucleus.
組織特異性：

Detected in heart, throughout the brain, placenta, lung, liver, muscle, kidney and pancreas. Also detected in spleen and peripheral blood leukocytes.
數據庫鏈接：

HGNC: 16804

OMIM: 602308

KEGG: hsa:11060

STRING: 9606.ENSP00000348283

UniGene: Hs.408458

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