WNT11 Antibody

說明書

中文名稱：

WNT11兔多克隆抗體
貨號：

CSB-PA991992
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA991992(WNT11 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA991992(WNT11 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
其他：

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靶點詳情

產品詳情

Uniprot No.：

O96014
基因名：

WNT11
別名：

HWNT11 antibody; Protein Wnt-11 antibody; Wingless-related MMTV integration site 11 antibody; Wingless-type MMTV integration site family, member 1 antibody; Wingless-type MMTV integration site family, member 11 antibody; Wingless-type MMTV integration site family, member 11B antibody; wnt-11 antibody; wnt11 antibody; WNT11_HUMAN antibody; wnt11b antibody
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Fusion protein of Human WNT11
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
IHC	1:25-1:100

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.
基因功能參考文獻：
1. FZD8 co-localizes and co-immunoprecipitates with Wnt-11 and potentiates Wnt-11 activation of ATF2-dependent transcription PMID: 29717114
2. we found that the hypoxic environment of the perivenular zone promotes Wnt11 expression in hepatocytes, which then regulates unique gene expression via activation of the non-canonical Wnt pathway PMID: 29244788
3. TGF-beta1-induced sm-alpha-actin expression is mediated by WNT-11 via RhoA activation and subsequent actin cytoskeletal remodeling. PMID: 27422998
4. The positive rates of Wnt11 protein in normal esophageal epithelium tissue was 29.8% and in esophageal carcinomas tissue was 31.9%; there was no significant difference between the two groups PMID: 27628667
5. Data suggest that Wnt-11 may serve as a target for cervical cancer therapy. PMID: 27034261
6. The Wnt11 gene plays an important role in human mesenchymal stromal cells for enhancing the osteogenesis in an infectious environment. PMID: 26818191
7. Demonstrate immunohistochemical expression of Wnt11 and BCL2A1 in complete moles and normal villi. PMID: 27386628
8. Report high expression of Wnt11 in esophageal squamous cell carcinoma, which was significantly associated with AJCC stage. PMID: 26261605
9. Notch1-induced WISP-1 expression appeared to be Wnt11-dependent, but Wnt1-independent PMID: 22715413
10. High expression of Wnt-11 is associated with metastasis in cervical cancer. PMID: 24737009
11. Data established a seven-gene (AR, ESR2, GATA3, GBX2, KRT16, MMP28 and WNT11) prognostic signature to define a subset of triple-negative breast cancer (TNBC). PMID: 23549873
12. Estrogen/progesterone treatment of mature myometrial cells induced expression of WNT11 and WNT16, which remained constitutively elevated in leiomyoma tissues. PMID: 24082114
13. Wnt11 mRNA expression was significantly higher in the stage I, II, III, or IV colorectal tumor tissues than in non-tumor colon. PMID: 22161723
14. Wnt11 is involved in the protection of the host intestinal cells by blocking the invasion of pathogenic bacteria, suppressing inflammation, and inhibiting apoptosis. PMID: 21903761
15. WNT11 emerged as a direct target of ERG. PMID: 21242973
16. These observations highlight the distinct roles of WNT11 and WNT4 during the early stages of retinoic acid-induced neuronal differentiation. PMID: 21280163
17. Data provide evidence for an autocrine regulatory loop involving transcriptional upregulation of WNT11 by ERRalpha and beta-cat that influences the migratory capacity of cancer cells. PMID: 20870744
18. These observations suggest a novel role for Wnt11 as a tumor suppressor during hepatocarcinogenesis because loss of expression promotes the malignant phenotype via both canonical and noncanonical Wnt signaling pathways. PMID: 20103596
19. These observations suggest that the increased level of Wnt-11 found in prostate cancer contributes to tumour progression by promoting neuroendocrine-like differentiation. PMID: 20219091
20. WNT11 mRNA was up-regulated in four cases of colorectal adenocarcinoma, and a case of renal cell carcinoma. Up-regulation of WNT11 mRNA might play an important role in human carcinogenesis through activation of the WNT signaling pathway. PMID: 11712081
21. Wnt11 stimulates proliferation, migration, cytoskeletal rearrangement, and contact-independent growth by a beta-catenin-independent mechanism PMID: 15084607
22. Wnt11 promotes cardiac differentiation via the non-canonical PKC-dependent signaling pathway PMID: 15701629
23. Wnt11 gene is expressed during early embryonic development and has a critical role in regulation of gastrulation movements. PMID: 15708567
24. Wnt-11 promotes cell viability and is involved in coordination of key signaling pathways. PMID: 18572162
25. Our study reveals an unappreciated role for noncanonical Wnt signaling in hESC specification that involves development of unique mesoderm precursors via morphogenic organization within human EBs. PMID: 19265664
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亞細胞定位：

Secreted, extracellular space, extracellular matrix.
蛋白家族：

Wnt family
組織特異性：

Expressed in fetal lung, kidney, adult heart, liver, skeletal muscle, and pancreas.
數據庫鏈接：

HGNC: 12776

OMIM: 603699

KEGG: hsa:7481

STRING: 9606.ENSP00000325526

UniGene: Hs.108219

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