WIPF2 Antibody

中文名稱：

WIPF2兔多克隆抗體
貨號：

CSB-PA823478LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA823478LA01HU diluted at 1:500 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA823478LA01HU diluted at 1:500 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) WIPF2 Polyclonal antibody
Uniprot No.：

Q8TF74
基因名：

WIPF2
別名：

WIPF2 antibody; WICH antibody; WIRE antibody; PP10631 antibody; WAS/WASL-interacting protein family member 2 antibody; WASP-interacting protein-related protein antibody; WIP- and CR16-homologous protein antibody; WIP-related protein antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human WAS/WASL-interacting protein family member 2 protein (18-176AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，WIPF2 Antibody (CSB-PA823478LA01HU)，的標記方式是Non-conjugated。對于WIPF2 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA823478LB01HU	WIPF2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA823478LC01HU	WIPF2 Antibody, FITC conjugated
Biotin	CSB-PA823478LD01HU	WIPF2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:500-1:1000

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system.
基因功能參考文獻：
1. Study provides evidence that WIP and WIRE contribute to breast cancer cell invasiveness through coordinated roles. WIP seems necessary for the assembly of invasive protrusions, whereas WIRE regulates their maturation, which leads to matrix degradation. PMID: 27009365
2. Data indicate that the reduced vimentin expression in response to EPHB4, WIPF2 and MTHFD2 silencing was observed at mRNA and protein levels. PMID: 23295955
3. The WASP-binding protein WIRE has a role in the regulation of the actin filament system downstream of the platelet-derived growth factor receptor PMID: 12213210
亞細胞定位：

Cytoplasm, cytoskeleton. Note=Localized to stress fibers and bundles of actin filaments.
蛋白家族：

Verprolin family
組織特異性：

Expressed mainly in brain, colon, lung and stomach (at protein level). Ubiquitously expressed, with high expression in brain, kidney, lung, and placenta.
數據庫鏈接：

HGNC: 30923

OMIM: 609692

KEGG: hsa:147179

STRING: 9606.ENSP00000320924

UniGene: Hs.421622

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