WEE2 Antibody

說明書

產品詳情

Uniprot No.：

P0C1S8
基因名：

WEE2
別名：

hCG_39453 antibody; WEE1 homolog 2 (S. pombe) antibody; Wee1-like protein kinase 1B antibody; Wee1-like protein kinase 2 antibody; WEE1B antibody; Wee1B kinase antibody; Wee2 antibody; WEE2_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthesized peptide derived from the Internal region of Human Wee 2.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:5000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1/CDC2 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation.
基因功能參考文獻：
1. homozygous mutations in WEE2 that are responsible for fertilization failure in humans, were identified. PMID: 29606300
亞細胞定位：

Nucleus.
蛋白家族：

Protein kinase superfamily, Ser/Thr protein kinase family, WEE1 subfamily
組織特異性：

Expressed in oocytes (at protein level). May also be expressed in testis.
數據庫鏈接：

HGNC: 19684

OMIM: 614084

KEGG: hsa:494551

STRING: 9606.ENSP00000380675

UniGene: Hs.657927

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