WDR4 Antibody

說明書

產(chǎn)品詳情

Uniprot No.：

P57081
基因名：

WDR4
別名：

OTTHUMP00000109401 antibody; OTTHUMP00000109402 antibody; TRM82 antibody; tRNA (guanine N(7) ) methyltransferase subunit WDR4 antibody; tRNA (guanine-N(7)-)-methyltransferase subunit WDR4 antibody; WD repeat containing protein 4 antibody; WD repeat protein 4 antibody; WD repeat protein domain 4 protein isoform 2 antibody; WD repeat-containing protein 4 antibody; wdr4 antibody; WDR4_HUMAN antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse,Rat
免疫原：

Human WDR4
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Non-catalytic component of a methyltransferase complex required for the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs). In the methyltransferase complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. Also required for the formation of N(7)-methylguanine at internal sites in a subset of mRNAs. Also required for methylation of a specific subset of miRNAs, such as let-7. Independently of METTL1, also plays a role in genome stability: localizes at the DNA replication site and regulates endonucleolytic activities of FEN1.
基因功能參考文獻：
1. WDR4 is an oncoprotein that negatively regulates PML via ubiquitination to promote lung cancer progression by fostering an immunosuppressive and prometastatic tumor microenvironment PMID: 28691927
2. Combined autozygome/exome analysis revealed a novel missense mutation in WDR4 as the likely causal variant of Primordial dwarfism PMID: 26416026
3. regulates FEN1's potential DNA cleavage threat near the site of replication PMID: 26751069
亞細胞定位：

Nucleus. Chromosome.
蛋白家族：

WD repeat TRM82 family
數(shù)據(jù)庫鏈接：

HGNC: 12756

OMIM: 605924

KEGG: hsa:10785

STRING: 9606.ENSP00000328671

UniGene: Hs.248815

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