WARS2 Antibody
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中文名稱：WARS2兔多克隆抗體
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貨號：CSB-PA025966GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：WARS2
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別名：WARS2 antibody; Tryptophan--tRNA ligase antibody; mitochondrial antibody; EC 6.1.1.2; antibody; Mt)TrpRS antibody; Tryptophanyl-tRNA synthetase antibody; TrpRS antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human WARS2
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Mitochondrial aminoacyl-tRNA synthetase that activate and transfer the amino acids to their corresponding tRNAs during the translation of mitochondrial genes and protein synthesis.
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基因功能參考文獻：
- An alternative conformation of human TrpRS suggests a role of zinc in activating non-enzymatic function. PMID: 28910573
- The data demonstrate a pro-angiogenic function for Wars2 both within and outside the heart. PMID: 27389904
- This confidently implicates that mutations in WARS2 cause mitochondrial disease with a broad spectrum of clinical presentation. PMID: 28905505
- we found a compound heterozygous genotype of the mitochondrial tryptophanyl-tRNA synthetase (WARS2) gene, comprising a nonsense mutation (c.325delA, p.Ser109Alafs*15), which very likely entails nonsense-mediated mRNA decay and a missense mutation PMID: 28236339
- Here we substantially extend and consolidate the symptomatology of WARS2 by presenting a patient with severe infantile-onset leukoencephalopathy, profound intellectual disability, spastic quadriplegia, epilepsy, microcephaly, short stature, failure to thrive, cerebral atrophy, and periventricular white matter abnormalities PMID: 28650581
- first genome-wide scan for selection in Inuit from Greenland. A region, with a deeply divergent haplotype that is closely related to the sequence in the Denisovan genome contains two genes, WARS2 and TBX15. our study suggests a complex multi-factorial regulation of TBX15 and WARS2. We show that the introgressed region is associated with regional changes in methylation and expression levels PMID: 28007980
- tandem promoters provide a dual system to regulate expression and alternative splicing of human TrpRS in vivo PMID: 14757836
- Mutations located at the appended beta1-beta2 hairpin and the AIDQ sequence of human TrpRS switch this enzyme to a tRNA-dependent mode in the tryptophan activation step. PMID: 17726052
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相關疾?。?/div>Neurodevelopmental disorder, mitochondrial, with abnormal movements and lactic acidosis, with or without seizures (NEMMLAS)亞細胞定位：Mitochondrion matrix.蛋白家族：Class-I aminoacyl-tRNA synthetase family組織特異性：Brain.數據庫鏈接：
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