VTI1A Antibody

中文名稱：

VTI1A兔多克隆抗體
貨號：

CSB-PA842635LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA842635LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA842635LA01HU at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA842635LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) VTI1A Polyclonal antibody
Uniprot No.：

Q96AJ9
基因名：

VTI1A
別名：

MMDS3 antibody; MVti1 antibody; SNARE Vti1a beta protein antibody; Vesicle transport through interaction with t-SNAREs homolog 1A antibody; Vesicle transport through interaction with tSNAREs homolog 1A (yeast) antibody; Vesicle transport v-SNARE protein Vti1-like 2 antibody; Vti1 rp2 antibody; Vti1-rp2 antibody; Vti1a antibody; VTI1A vesicle transport through interaction with t-SNAREs 1A antibody; VTI1A_HUMAN antibody; VTI1RP2 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Vesicle transport through interaction with t-SNAREs homolog 1A protein (1-175AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，VTI1A Antibody (CSB-PA842635LA01HU)，的標記方式是Non-conjugated。對于VTI1A Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA842635LB01HU	VTI1A Antibody, HRP conjugated	ELISA
FITC	CSB-PA842635LC01HU	VTI1A Antibody, FITC conjugated
Biotin	CSB-PA842635LD01HU	VTI1A Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence.
基因功能參考文獻：
1. Novel variants of VTI1A-TCF7L2 fusion transcripts, including a novel fusion partner gene, RP11-57H14.3, was identified and demonstrated detectable levels in a large fraction of colorectal cancer samples.[RP11-57H14.3] PMID: 24608966
2. our results indicate that genetic variants in VTI1A may modify individual susceptibility to non-GBM of glioma in the Han Chinese population and support the role of the VTI1A genes in the occurrence of glioma. PMID: 28320150
3. The AA genotype of VTI1A (rs7086803) polymorphism had an increased risk of developing NSCLC compared with the GG genotype. Smoking lung cancer patients with the AA genotype of VTI1A gene (rs7086803) had a poor survival rate. PMID: 25744365
4. analysis of a new susceptibility locus for colorectal cancer in VTI1A [meta-analysis] PMID: 25105248
5. Data indicate that depletion of VAMP4, syntaxin 6, syntaxin 16, and Vti1a disrupted the Golgi ribbon structure. PMID: 23677696
6. We found a colorectal carcinoma cell line harboring the fusion gene to be dependent on VTI1A-TCF7L2 for anchorage-independent growth using RNA interference-mediated knockdown. PMID: 21892161
7. The present results suggest that a SNARE complex containing VAMP7 and Vti1a defines a novel traffic pathway to the cell surface in both neuronal and non-neuronal cells. PMID: 19138172
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亞細胞定位：

Cytoplasmic vesicle. Golgi apparatus membrane; Single-pass type IV membrane protein.
蛋白家族：

VTI1 family
數據庫鏈接：

HGNC: 17792

OMIM: 614316

KEGG: hsa:143187

STRING: 9606.ENSP00000376792

UniGene: Hs.194554

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