VSIR Antibody, FITC conjugated
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中文名稱：VSIR兔多克隆抗體, FITC偶聯(lián)
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貨號：CSB-PA884484LC01HU
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規(guī)格：￥880
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) VSIR Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：B7 H5 antibody; B7H5 antibody; C10orf54 antibody; chromosome 10 open reading frame 54 antibody; DD1alpha antibody; GI24 antibody; GI24_HUMAN antibody; PD-1H antibody; PDCD1 homolog antibody; Platelet receptor Gi24 antibody; PP2135 antibody; sisp 1 antibody; SISP1 antibody; stress induced secreted protein 1 antibody; UNQ730/PRO1412 antibody; V domain Ig suppressor of T cell activation antibody; V set domain containing immunoregulatory receptor antibody; V set immunoregulatory receptor antibody; V type immunoglobulin domain containing suppressor of T cell activation antibody; VISTA antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human V-type immunoglobulin domain-containing suppressor of T-cell activation protein (37-194AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
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靶點詳情
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功能：Immunoregulatory receptor which inhibits the T-cell response. May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling. May stimulate MMP14-mediated MMP2 activation.
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基因功能參考文獻：
- Data indicate that VISTA is predominantly expressed and up-regulated in the high-density infiltrated immune cells but minimal in pancreatic cancerous cells. PMID: 29771768
- High VISTA expression is associated with colorectal carcinoma. PMID: 30128738
- VISTA expression supports immune-complex inflammation in collagen antibody-induced arthritis and VISTA is expressed in human synovium PMID: 29216931
- This study is the first to describe the expression of VISTA-expressing lymphocytes in melanoma samples and in the context of acquired resistance to immune checkpoint inhibitors PMID: 28776578
- Taken together, the results indicated that the VISTA high and CD8 low group, as an immunosuppressive subgroup, might be associated with a poor prognosis in primary OSCC. These findings indicated that VISTA might be a potential immunotherapeutic target in OSCC treatment. PMID: 28236118
- this review describes the functions of VISTA in the context of cancer immunotherapy PMID: 28258694
- overexpression of the newly described co-stimulatory molecule, PD1 homologue (PD-1H) in human monocyte/macrophages is sufficient to induce spontaneous secretion of multiple cytokines. PMID: 25279955
- p53-induced expression of DD1alpha prevents persistence of cell corpses and ensures efficient generation of precise immune responses in mice. PMID: 26228159
- Results suggest that GI24 contributes to tumor-invasive growth in the collagen matrix by augmenting cell surface MT1-MMP. PMID: 20666777
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亞細(xì)胞定位：Cell membrane; Single-pass type I membrane protein.
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組織特異性：Expressed in spleen. Detected on a number of myeloid cells including CD11b monocytes, CD66b+ neutrophils, at low levels on CD4+ and CD8+ T-cells, and in a subset of NK cells. Not detected on B cells (at protein level). Expressed at high levels in placenta
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