VPS37A Antibody
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中文名稱：VPS37A兔多克隆抗體
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貨號：CSB-PA567081
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規格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA567081(VPS37A Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200) -
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA567081(VPS37A Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200) -
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human fetal liver tissue and hela cell, Primary antibody: CSB-PA567081(VPS37A Antibody) at dilution 1/200 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 15 seconds
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：VPS37A antibody; HCRP1 antibody; Vacuolar protein sorting-associated protein 37A antibody; hVps37A antibody; ESCRT-I complex subunit VPS37A antibody; Hepatocellular carcinoma-related protein 1 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse
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免疫原：Fusion protein of Human VPS37A
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:1000-1:2000 WB 1:200-1:1000 IHC 1:25-1:100 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
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基因功能參考文獻：
- HCRP1 is a negative regulator in prostate cancer progression, metastasis and multi-drug resistance. PMID: 28458158
- this study identifies HCRP1 downregulation correlates with tumor stage, nodal metastasis, and poor patient survival in human gastric cancer PMID: 28963677
- The present data indicate that HCRP1 inhibits breast cancer metastasis through downregulating EGFR phosphorylation. PMID: 27311861
- Low HCRP1 expression was found to be of adverse prognostic significance in patients with oral and oropharyngeal squamous cell carcinoma who received preoperative chemoradiotherapy PMID: 22891969
- The missense mutation c.1146A>T in Vps37A causes autosomal recessive complex hereditary spastic paraparesis. PMID: 22717650
- Data show hVps37A mRNA downregulation in ovarian cancer. PMID: 22016507
- Our results strongly suggest that HCRP1 might be a growth inhibitory protein and associated with decreasing the invasion of HCC cells PMID: 14623289
- HCRP1 is a subunit of mammalian ESCRT-I, and its function is essential for lysosomal sorting of EGF receptors. PMID: 15240819
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相關疾病：Spastic paraplegia 53, autosomal recessive (SPG53)
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亞細胞定位：Late endosome membrane; Peripheral membrane protein. Nucleus.
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蛋白家族：VPS37 family
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組織特異性：Widely expressed. Examined tissues include heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. More abundant in liver. Strongly decreased or undetected in hepatomas.
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數據庫鏈接：
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