VPS11 Antibody

說明書

中文名稱：

VPS11兔多克隆抗體
貨號：

CSB-PA887959ESR2HU
規(guī)格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA887959ESR2HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human bladder cancer using CSB-PA887959ESR2HU at dilution of 1:100
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) VPS11 Polyclonal antibody
Uniprot No.：

Q9H270
基因名：

VPS11
別名：

END1 antibody; HGNC:14583 antibody; hVPS11 antibody; PEP5 antibody; PP3476 antibody; RING finger protein 108 antibody; RNF108 antibody; Vacuolar protein sorting 11 (yeast homolog) antibody; Vacuolar protein sorting 11 (yeast) antibody; Vacuolar protein sorting 11 homolog (S. cerevisiae) antibody; Vacuolar protein sorting 11 homolog antibody; Vacuolar protein sorting associated protein 11 homolog antibody; Vacuolar protein sorting protein 11 antibody; Vacuolar protein sorting-associated protein 11 homolog antibody; vps11 antibody; VPS11_HUMAN antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Vacuolar protein sorting-associated protein 11 homolog protein (692-941AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Required for fusion of endosomes and autophagosomes with lysosomes. Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes. Involved in the retrograde Shiga toxin transport.
基因功能參考文獻(xiàn)：
1. Underlining the presumed pathogenic potential of VPS11 defects. PMID: 27473128
2. our study reveals a defect in VPS11 as the underlying etiology for an autosomal recessive leukoencephalopathy disorder associated with a dysfunctional autophagy-lysosome trafficking pathway PMID: 27120463
3. In Ashkenazi-Jewish patients, syndrome with hypomyelination, developmental delay, increasing appendicular spasticity, truncal hypotonia and acquired microcephaly is associated with VPS11 missense mutation, p.Cys846Gly. PMID: 26307567
相關(guān)疾病：

Leukodystrophy, hypomyelinating, 12 (HLD12)
亞細(xì)胞定位：

Endosome. Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Cytoplasmic vesicle. Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle, clathrin-coated vesicle.
蛋白家族：

VPS11 family
組織特異性：

Ubiquitous. Expression was highest in heart and low in lung.
數(shù)據(jù)庫鏈接：

HGNC: 14583

OMIM: 608549

KEGG: hsa:55823

UniGene: Hs.234282

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