VNN1 Antibody

中文名稱：

VNN1兔多克隆抗體
貨號：

CSB-PA025883LA01HU
規(guī)格：

￥440
圖片：
Western Blot
Positive WB detected in: PC-3 whole cell lysate, HepG2 whole cell lysate, A549 whole cell lysate
All lanes: vnn1 antibody at 3.4μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 58 kDa
Observed band size: 58 kDa

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA025883LA01HU at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA025883LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) VNN1 Polyclonal antibody
Uniprot No.：

O95497
基因名：

VNN1
別名：

HDLCQ8 antibody; High density lipoprotein cholesterol level quantitative trait locus 8, included antibody; Pantetheinase antibody; Pantetheine hydrolase antibody; Tiff66 antibody; V-1 antibody; Vanin 1 antibody; Vanin-1 antibody; Vannin 1 antibody; Vascular non inflammatory molecule 1 antibody; Vascular non-inflammatory molecule 1 antibody; VNN 1 antibody; VNN1 antibody; VNN1_HUMAN antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Pantetheinase protein (97-197AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁面中的產(chǎn)品，VNN1 Antibody (CSB-PA025883LA01HU)，的標(biāo)記方式是Non-conjugated。對于VNN1 Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA025883LB01HU	VNN1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA025883LC01HU	VNN1 Antibody, FITC conjugated
Biotin	CSB-PA025883LD01HU	VNN1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, WB, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine.
基因功能參考文獻：
1. findings suggest that the metabolic pathway catalyzed by VNN1 pantetheinase plays a suppressive role in IAV infection in the respiratory tract, especially in severe conditions under hypercytokinemia PMID: 28576495
2. Data show that G protein-coupled receptor, family C, group 5, member A protein (GPRC5A) regulates oxidative stress through vanin 1 protein (VNN1). PMID: 28316092
3. These data suggest that urinary vanin-1 is an early predictive biomarker for decline in eGFR in patients with urothelial carcinoma after dosing of cisplatin PMID: 27317936
4. serum pantetheinas, encoded by the VNN1 gene, level regulates erythrocyte life span and modulates the risk of developing complicated malaria. PMID: 26343328
5. VNN1 contributes to corticosteroid responsiveness, and changes in VNN1 nasal epithelial mRNA expression and VNN1 promoter methylation might be clinically useful biomarkers of treatment response in asthmatic children. PMID: 25910714
6. Our study provides strong biological evidence for the association of the identified SNP with BP and suggests that vanin-1 misfolding and degradation are the underlying molecular mechanism. PMID: 25233454
7. show that hepatic vanin-1 is under extremely sensitive regulation by PPARalpha and that plasma vanin activity could serve as a readout of changes in PPARalpha activity in human subjects PMID: 24751833
8. The X-ray crystal structure of human vanin 1 at 2.25 A resolution is presented, which is the first reported structure from the vanin family, as well as a crystal structure of vanin 1 bound to a specific inhibitor. PMID: 25478849
9. Serum vanin-1 levels may be low in the end-stage renal failure and transiently increase after transplant owing to transient renal function deterioration, which does not lead to elevation of serum creatinine levels in renal transplant patients. PMID: 24702142
10. Our results suggest that vanin-1 can distinguish between chronic responders and non-responders ITP patients as well as between newly diagnosed ITP patients and healthy controls. PMID: 23534352
11. Alternative Splicing in VNN1 gene is associated with colorectal cancer. PMID: 24687856
12. Single-nucleotide polymorphisms in the Regulatory Regions of the VNN1 Gene Are Associated with inflammatory bowel diseases. PMID: 23949622
13. Microparticle internalization required the interaction of the ectoenzyme Vanin-1 (VNN1), an abundant surface protein on the microparticles, with lipid raft domains of endothelial cells. PMID: 24106341
14. It isthe enzyme that recycles pantothenic acid (vitamin B5) generated during coenzyme A breakdown and actively involved in the progression of inflammatory reactions by generating cysteamine. PMID: 23978960
15. Liver contributes to Vanin-1 secretion in serum and PPARalpha is a limiting factor in serum Vnn1 production. PMID: 24140347
16. data do not support a major role for the Vanin 1 T26I variant in determining blood pressure level and incident ischemic events PMID: 21550219
17. Our data suggest that VNN1 gene expression and the G-137T variant are associated with HDL-C levels in Mexican children, particularly in prepubertal girls. PMID: 23185446
18. Urinary vanin-1, an ectoenzyme pantetheinase, distinguished diabetic patients with macroalbuminuria from those with normal albuminuria. PMID: 21544065
19. Vanin-1 is a specific and sensitive biomarker for renal tubular injury induced by organic solvents. PMID: 21907259
20. Overexpression of VNN1, an oxidative stress sensor in epithelial cells, was most strongly associated with progression to chronic immune thrombocytopenia PMID: 21325602
21. The combination of VNN1 and MMP9 may be used as a novel blood biomarker panel for the discrimination of pancreatic cancer-associated diabetes from type 2 diabetes. PMID: 20571492
22. Pantetheinase (Vnn1) is critical for the host susceptibility to malaria. PMID: 17312006
23. missense SNP rs2272996 (or N131S) in the VNN1 gene was significantly associated with hypertension in African Americans and the association was replicated in Mexican Americans; a non-significant opposite association was observed in European Americans PMID: 18043751
24. vanin-1 and vanin-3 are induced at the mRNA and protein level by psoriasis-associated proinflammatory cytokines (Th17/Th1) but not by Th2 cytokines. PMID: 19322213
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亞細胞定位：

Cell membrane; Lipid-anchor, GPI-anchor.
蛋白家族：

Carbon-nitrogen hydrolase superfamily, BTD/VNN family
組織特異性：

Widely expressed with higher expression in spleen, kidney and blood. Overexpressed in lesional psoriatic skin.
數(shù)據(jù)庫鏈接：

HGNC: 12705

OMIM: 603570

KEGG: hsa:8876

STRING: 9606.ENSP00000356905

UniGene: Hs.12114

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