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中文名稱：VACWR106兔多克隆抗體
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貨號：CSB-PA366132XA01VAI
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規格：￥880
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圖片：
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Western Blot
Positive WB detected in: recombinant protein
All lanes:VACWR106 Antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 40.2 kDa
Observed band size: 41 kDa
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其他：
產品詳情
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產品名稱：Rabbit anti-Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) VACWR106 Antibody Polyclonal antibody
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Uniprot No.：
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基因名：VACWR106 Antibody
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別名：mRNA-capping enzyme catalytic subunit (Virus termination factor large subunit) (VTF large subunit) (mRNA-capping enzyme 97 kDa subunit) (mRNA-capping enzyme D1 subunit) (mRNA-capping enzyme large subunit) [Includes: Polynucleotide 5'-triphosphatase (EC 3.1.3.33) (mRNA 5'-triphosphatase) (TPase); mRNA guanylyltransferase (EC 2.7.7.50) (GTP--RNA guanylyltransferase) (GTase); mRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.56) (mRNA cap methyltransferase)] VACWR106 D1R
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宿主：Rabbit
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反應種屬：Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
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免疫原：Recombinant Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) VACWR106 protein (516-844aa)
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免疫原種屬：Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA, WB
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:5000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Catalytic subunit of the mRNA capping enzyme which catalyzes three enzymatic reactions: the 5' triphosphate end of the pre-mRNA is hydrolyzed to a diphosphate by RNA 5' triphosphatase; the diphosphate RNA end is capped with GMP by RNA guanylyltransferase and the GpppN cap is methylated by RNA (guanine-N7) methyltransferase. Heterodimeric mRNA capping enzyme catalyzes the linkage of a N7-methyl-guanosine moiety to the first transcribed nucleotide (cap 0 structure), whereas the polymerase associated VP39 is responsible for a second methylation at the 2'-O position of the ribose (cap 1 structure).; The heterodimeric enzyme is also involved in early viral gene transcription termination and intermediate viral gene transcription initiation. Early gene transcription termination requires the termination factor VTF, the DNA-dependent ATPase NPH-I and the Rap94 subunit of the viral RNA polymerase, as well as the presence of a specific termination motif. Binds, together with RAP94, to the termination motif 5'-UUUUUNU-3' in the nascent early mRNA.
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基因功能參考文獻：
- VTF provides the connection between the termination signal in the RNA transcript and viral RNA polymerase to initiate transcription termination. PMID: 26280468
- Crystal structure of vaccinia virus mRNA capping enzyme PMID: 24607143
- the results presented in this study provide the first in vivo evidence that the vaccinia virus mRNA capping enzyme plays a role in early gene transcription termination and intermediate gene transcription. PMID: 18295814
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亞細胞定位：Virion. Note=All the enzymes and other proteins required to synthesize early mRNAs are packaged within the virion core along with the DNA genome.
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蛋白家族：DsDNA virus mRNA guanylyltransferase family; Class I-like SAM-binding methyltransferase superfamily, mRNA cap 0 methyltransferase family
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數據庫鏈接：
KEGG: vg:3707562
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