USP30 Antibody
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中文名稱：USP30兔多克隆抗體
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貨號(hào)：CSB-PA004395
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規(guī)格：￥1090
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圖片：
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Western Blot analysis of HeLa cells using USP30 Polyclonal Antibody
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：
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別名：Deubiquitinating enzyme 30 antibody; FLJ40511 antibody; Ub-specific protease 30 antibody; Ubiquitin carboxyl terminal hydrolase 30 antibody; Ubiquitin carboxyl-terminal hydrolase 30 antibody; Ubiquitin specific peptidase 30 antibody; Ubiquitin specific processing protease 30 antibody; Ubiquitin thioesterase 30 antibody; Ubiquitin thiolesterase 30 antibody; Ubiquitin-specific-processing protease 30 antibody; UBP30_HUMAN antibody; usp30 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Synthesized peptide derived from the N-terminal region of Human USP30.
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：WB, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 ELISA 1:10000 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy. Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate in mitophagic signaling. Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65'. Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2.
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基因功能參考文獻(xiàn)：
- the role of USP30 in the dynamic networks of mitochondrial quality control and its physiological implications. PMID: 29178074
- Here the authors report crystal structures of human USP30 bound to monoubiquitin and Lys6-linked diubiquitin, which explain how USP30 achieves Lys6-linkage preference through unique ubiquitin binding interfaces. PMID: 28945249
- show that USP30 delays mitophagy by delaying PARK2 recruitment to the mitochondria during mitophagy PMID: 25915564
- These results provide the first evidence for a fundamental role of USP30 in determining the threshold for mitochondrial cell death and suggest USP30 as a potential target for combinatorial anti-cancer therapy. PMID: 25739811
- The mechanism by which parkin, an E3 ubiquitin ligase, and USP30, a mitochondrion-localized deubiquitylase, regulate mitophagy, was investigated. PMID: 25621951
- reducing USP30 activity enhances mitochondrial degradation in neurons PMID: 24896179
- USP30 participates in the maintenance of mitochondrial morphology, a finding that provides new insight into the cellular function of deubiquitination. PMID: 18287522
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亞細(xì)胞定位：Mitochondrion outer membrane.
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蛋白家族：Peptidase C19 family
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組織特異性：Expressed in skeletal muscle, pancreas, liver and kidney.
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數(shù)據(jù)庫鏈接：
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