US12 Antibody

^{Rare Species}

說明書

產品詳情

Uniprot No.：

P03170
基因名：

US12
別名：

ICP47 protein (Immediate-early protein IE12) (Immediate-early-5) (Infected cell protein 47) (US12 protein) (Vmw12), US12
反應種屬：

Human herpesvirus 1
免疫原：

Recombinant Human herpesvirus 1 ICP47 protein (US12) (1-88aa)
免疫原種屬：

Human herpesvirus 1
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Protein G
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Plays a role in the inhibition of host immune response. Binds specifically to transporters associated with antigen processing (TAP), thereby blocking peptide-binding and translocation by TAP as well as subsequent loading of peptides onto MHC class I molecules. Empty MHC I molecules are retained in the endoplasmic reticulum and ultimately directed to proteasomal degradation. In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes.
基因功能參考文獻：
1. The structure shows that herpes simplex virus ICP47 traps human TAP in an inactive conformation distinct from the normal transport cycle. PMID: 27935481
2. cryo-electron microscopy structure of human TAP in complex with its inhibitor ICP47, a small protein produced by the herpes simplex virus I PMID: 26789246
3. Results indicate that recombinant adenovirus r-H-ICP47 had the abilities of reducing the proliferation of lymphocytes activated by dendritic cells (DCs). PMID: 23774531
亞細胞定位：

Host cytoplasm. Host nucleus.
蛋白家族：

Herpesviridae US12 family
數據庫鏈接：

KEGG: vg:2703441

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