URI1 Antibody
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中文名稱：URI1兔多克隆抗體
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貨號(hào)：CSB-PA993836
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規(guī)格：￥2024
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圖片：
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Western blot analysis of extracts from NIH/3T3 cells, using RMP antibody. -
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using RMP antibody.
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) URI1 Polyclonal antibody
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Uniprot No.：
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基因名：URI1
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Synthesized peptide derived from C-terminal of Human RMP.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB,IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 IHC 1:50-1:100 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein.; Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination.
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基因功能參考文獻(xiàn)：
- Collectively, these findings indicate that RMP promotes Epithelial-mesenchymal transition and hepatocellular carcinoma metastasis through NF-kappaB/CSN2/Snail pathway. These results suggest that RMP and p65 may serve as potential candidates of the targets in the treatment of metastatic hepatocellular carcinoma. PMID: 28423737
- These findings suggest that URI1 has properties of a 'non-oncogene' that supports the oncogenic phenotype of those cancer cells that have evolved a dependency on this molecular chaperone system for survival PMID: 27105489
- Amplification of 19q12 CCNE1/URI was found in 10.4% (28/270) and was significantly associated with type II endometrial cancer (EC) high grade, advanced FIGO stage, and aberrant tumor supressor p53 expression. PMID: 27582547
- that KAP1 phosphorylation is decreased following recruitment of PP2A by URI. PMID: 27780869
- RMP status in tumors may be a useful marker in estimating prognosis in patients with hepatocellular carcinoma and in assisting in the selection of patients who are likely to benefit from adjuvant TACE to prevent relapse. PMID: 25605019
- High URI1 expression is associated with epithelial ovarian cancer. PMID: 25527175
- Results show that URI expression is essential for hepatocarcinogenesis and associated with poor survival. PMID: 25453901
- URI may have an important role in the development of multiple myeloma and chemotherapeutic resistance through activation of the IL-6/STAT3 pathway. PMID: 24625985
- Higher level of URI/RMP expression in high-grade endometrioid adenocarcinomas compared to tissues of adjacent endometrium or gland suggests a diagnostic and possibly, a prognostic value of URI/RMP in endometrioid adenocarcinoma. PMID: 24228101
- Data show that URI is an "addicting" oncogene selectively required for the survival of ovarian cancer cells with increased URI copy number. PMID: 21397856
- a component of a signaling pathway that coordinates nutrient availability with gene expression PMID: 14615539
- Data show that URI and PP1gamma are components of an S6K1-regulated mitochondrial pathway dedicated to oppose sustained S6K1 survival signaling and to ensure that the threshold for apoptosis is set based on nutrient and growth factor availability. PMID: 17936702
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亞細(xì)胞定位：Nucleus. Cytoplasm. Mitochondrion. Cell projection, dendrite. Note=Colocalizes with PFDN2, PFDN4, PPP1CC, RPS6KB1 and STAP1 at mitochondrion.
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蛋白家族：RNA polymerase II subunit 5-mediating protein family
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組織特異性：Ubiquitous. Expressed in ovarian cancers (at protein level). Expressed strongly in skeletal muscle. Expressed weakly in brain, heart, pancreas and in prostate epithelial cells.
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數(shù)據(jù)庫(kù)鏈接：
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