UNC50 Antibody

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) UNC50 Polyclonal antibody
Uniprot No.：

Q53HI1
基因名：

UNC50
別名：

UNC50; UNCL; HSD-23; HSD23; Protein unc-50 homolog; Periodontal ligament-specific protein 22; PDLs22; Protein GMH1 homolog; hGMH1; Uncoordinated-like protein
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Protein unc-50 homolog protein (15-82AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，UNC50 Antibody (CSB-PA687496LA01HU)，的標記方式是Non-conjugated。對于UNC50 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA687496LB01HU	UNC50 Antibody, HRP conjugated	ELISA
FITC	CSB-PA687496LC01HU	UNC50 Antibody, FITC conjugated
Biotin	CSB-PA687496LD01HU	UNC50 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Involved in the cell surface expression of neuronal nicotinic receptors. Binds RNA.
基因功能參考文獻：
1. Data indicate that biallelic mutation in the UNC50 gene underlies AMC through a probable loss of AChR expression at the neuromuscular junction which is essential for the cholinergic transmission during human muscle development. PMID: 29016857
2. depletion of UNC50 blocked early endosome-to-Golgi trafficking and induced lysosomal degradation of STx2. UNC50 acted by recruiting GBF1, an ADP ribosylation factor-guanine nucleotide exchange factor (ARF-GEF), to the Golgi. PMID: 28883040
3. UNC50 may plays some roles in HCC progression by affecting the EGFR pathway PMID: 25738771
4. UNCL plays important roles in the development, differentiation, and maintenance of periodontal tissues and in the mechanotransduction of periodontal ligament fibroblasts. PMID: 17004066
亞細胞定位：

Nucleus inner membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
蛋白家族：

Unc-50 family
組織特異性：

Present in periodontal ligament fibroblasts (at protein level).
數據庫鏈接：

HGNC: 16046

OMIM: 617826

KEGG: hsa:25972

STRING: 9606.ENSP00000350409

UniGene: Hs.13370

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