UBXN6 Antibody

中文名稱：

UBXN6兔多克隆抗體
貨號：

CSB-PA874859LA01HU
規格：

￥440
圖片：
Western blot
All lanes: UBXN6 antibody at 1.2μg/ml
Lane 1: PC-3 whole cell lysate
Lane 2: Hela whole cell lysate
Lane 3: Mouse kidney tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 50, 44 kDa
Observed band size: 50 kDa

Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA874859LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA874859LA01HU at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) UBXN6 Polyclonal antibody
Uniprot No.：

Q9BZV1
基因名：

UBXN6
別名：

UBX domain containing 1 antibody; UBX domain containing 2 antibody; UBX domain containing protein 1 antibody; UBX domain containing protein 6 antibody; UBX domain protein 6 antibody; UBX domain-containing protein 1 antibody; UBX domain-containing protein 6 antibody; UBXD1 antibody; UBXDC2 antibody; Ubxn6 antibody; UBXN6_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human, Mouse
免疫原：

Recombinant Human UBX domain-containing protein 6 protein (1-388AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，UBXN6 Antibody (CSB-PA874859LA01HU)，的標記方式是Non-conjugated。對于UBXN6 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA874859LB01HU	UBXN6 Antibody, HRP conjugated	ELISA
FITC	CSB-PA874859LC01HU	UBXN6 Antibody, FITC conjugated
Biotin	CSB-PA874859LD01HU	UBXN6 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes. As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation. It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes.
基因功能參考文獻：
1. These results indicate that the outer membrane protein MCL1 is degraded by the VCP-UBXD1 complex and that the process is promoted by the presence of mutant Huntingtin. PMID: 27913212
2. UBXD1-N intercalates into the p97-ND1 interface, thereby modulating interdomain communication of p97 domains and its activity with relevance for disease pathogenesis PMID: 26475856
3. Data indicate that endosomal trafficking of CAV1 depends on ubiquitination of the N-terminal region and the subsequent recruitment of VCP-UBXD1. PMID: 23335559
4. UBXD1 modulates the trafficking of ERGIC-53-containing vesicles by controlling the interaction of transport factors with the cytoplasmic tail of ERGIC-53. PMID: 22337587
5. Data show that expression of VCP mutant proteins, or siRNA-mediated depletion of UBXD1 leads to a block of CAV1 transport at the limiting membrane of enlarged endosomes in cultured cells. PMID: 21822278
6. UBXD1 is a novel co-factor of the human p97 ATPase. PMID: 18656546
7. An additional p97 binding site in UBXD1 that competed with the p47 cofactor for binding to the N domain of p97 was identified. PMID: 19174149
8. these findings suggest that UBXD1 is a regulatory component of endoplasmic reticulum-associated degradation that may modulate the adaptor binding to VCP. PMID: 19275885
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亞細胞定位：

Cytoplasm. Cytoplasm, cytosol. Membrane; Peripheral membrane protein. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Early endosome membrane; Peripheral membrane protein. Late endosome membrane; Peripheral membrane protein. Lysosome membrane; Peripheral membrane protein.
組織特異性：

Enhanced expression in testis.
數據庫鏈接：

HGNC: 14928

OMIM: 611946

KEGG: hsa:80700

STRING: 9606.ENSP00000301281

UniGene: Hs.435255

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