UBE2D2 Antibody, HRP conjugated

說明書

中文名稱：

UBE2D2兔多克隆抗體, HRP偶聯(lián)
貨號：

CSB-PA025444LB01HU
規(guī)格：

￥880
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) UBE2D2 Polyclonal antibody
Uniprot No.：

P62837
基因名：

UBE2D2
別名：

E2(17)KB2 antibody; OTTHUMP00000223475 antibody; OTTHUMP00000223476 antibody; OTTHUMP00000223477 antibody; OTTHUMP00000223478 antibody; OTTHUMP00000224375 antibody; PUBC 1 antibody; PUBC1 antibody; UB2D2_HUMAN antibody; UBC 4 antibody; UBC 4/5 antibody; UBC4 antibody; UBC4/5 antibody; UBC4/5 homolog yeast antibody; UBCH 5B antibody; UBCH5B antibody; UBE2D2 antibody; Ubiquitin carrier protein antibody; Ubiquitin carrier protein D2 antibody; Ubiquitin conjugating enzyme E2 17 kDa 2 antibody; Ubiquitin conjugating enzyme E2 D2 antibody; Ubiquitin conjugating enzyme E2D 2 (homologous to yeast UBC4/5) antibody; Ubiquitin conjugating enzyme E2D 2 (UBC4/5 homolog yeast) antibody; Ubiquitin conjugating enzyme E2D 2 antibody; Ubiquitin protein ligase D2 antibody; Ubiquitin-conjugating enzyme E2 D2 antibody; Ubiquitin-conjugating enzyme E2(17)KB 2 antibody; Ubiquitin-conjugating enzyme E2-17 kDa 2 antibody; Ubiquitin-protein ligase D2 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Ubiquitin-conjugating enzyme E2 D2 protein (1-147AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3.
基因功能參考文獻(xiàn)：
1. Knockdown of UBE2D2 caused an increase in p53 protein levels, and knockdown of p53 attenuated not only cadmium-induced apoptosis, but also cadmium-induced apoptosis-related gene expression. PMID: 26912277
2. mutations having marked effects on function only minimally affect the intermolecular interactions between the AO7 RING and UbcH5B, establishing a high degree of complexity in activation through the RING-E2 interface. PMID: 26475854
3. together with UBE2L3 and UBE2N, synergistically contribute to Parkin-mediated mitophagy PMID: 24906799
4. Presented is the structure of the human dimeric RING domain from BIRC7 in complex with the E2 UbcH5B covalently linked to Ub. PMID: 22902369
5. determined the 2.2 A crystal structure of an intermediate of UbcH5b approximately ubiquitin (Ub) conjugate, which is assembled into an infinite spiral through the backside interaction. PMID: 20152160
6. role of WW3 and WW4 domains of Nedd4-2 in dopamine transporter ubiquitination was demonstrated; siRNA analysis demonstrated that this polyubiquitination is mediated by Nedd4-2 cooperation with UBE2D and UBE2L3 E2 ubiquitin-conjugating enzymes PMID: 20051513
7. Results describe the crystal structure of a complex between the HECT domain of NEDD4L and the E2 UbcH5B bearing a covalently linked Ub at its active site (UbcH5B approximately Ub). PMID: 20064473
8. Data show that binding of the CNOT4 RING finger to the ubiquitin-conjugating enzyme (E2) UbcH5B is highly selective. PMID: 15001359
9. UbcH5B/C are E2s for Mdm2, which contribute to the maintenance of low levels of p53 and Mdm2 in unstressed cells; inhibition of p53 ubiquitination and degradation by targeting UbcH5B/C is not sufficient to up-regulate p53 transcriptional activity. PMID: 15280377
10. Ubc4/5 and c-Cbl continue to ubiquitinate EGF receptor after internalization to facilitate polyubiquitination and degradation PMID: 18508924
11. UBE2D2 is required for GCMa ubiquitination and for association with the SCF(FBXW2) complex. PMID: 18703417
12. The results imply that the interaction specificity between c-Cbl, UbcH7 and UbcH5b is required but not sufficient for transfer of ubiquitin to potential targets. PMID: 18996392
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蛋白家族：

Ubiquitin-conjugating enzyme family
數(shù)據(jù)庫鏈接：

HGNC: 12475

OMIM: 602962

KEGG: hsa:7322

STRING: 9606.ENSP00000381717

UniGene: Hs.108332

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