UBE2D1 Antibody

中文名稱：

UBE2D1兔多克隆抗體
貨號：

CSB-PA025443DA01HU
規格：

￥440
圖片：
Western blot
All lanes: UBE2D1 antibody at 2µg/ml
Lane 1: Mouse thymus tissue
Lane 2: NIH/3T3 whole cell lysate
Lane 3: Jurkat whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 17 kDa
Observed band size: 17 kDa

Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA025443DA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA025443DA01HU at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) UBE2D1 Polyclonal antibody
Uniprot No.：

P51668
基因名：

UBE2D1
別名：

E2(17)KB1 antibody; SFT antibody; Stimulator of Fe transport antibody; UB2D1_HUMAN antibody; UBC 4/5 antibody; UBC4/5 antibody; UBC4/5 homolog antibody; UBC4/5, S. cerevisiae, homolog of antibody; UBCH 5 antibody; UBCH 5A antibody; UbcH5 antibody; UBCH5A antibody; Ube2d1 antibody; Ubiquitin carrier protein antibody; Ubiquitin carrier protein D1 antibody; Ubiquitin conjugating enzyme E2 17 kDa 1 antibody; Ubiquitin conjugating enzyme E2 D1 antibody; Ubiquitin conjugating enzyme E2D 1 (UBC4/5 homolog yeast) antibody; Ubiquitin conjugating enzyme E2D 1 antibody; Ubiquitin conjugating enzyme UBCH5A antibody; Ubiquitin protein ligase D1 antibody; Ubiquitin-conjugating enzyme E2 D1 antibody; Ubiquitin-conjugating enzyme E2(17)KB 1 antibody; Ubiquitin-conjugating enzyme E2-17 kDa 1 antibody; Ubiquitin-protein ligase D1 antibody
宿主：

Rabbit
反應種屬：

Human, Mouse
免疫原：

Recombinant Human Ubiquitin-conjugating enzyme E2 D1 protein (1-147AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，UBE2D1 Antibody (CSB-PA025443DA01HU)，的標記方式是Non-conjugated。對于UBE2D1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA025443DB01HU	UBE2D1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA025443DC01HU	UBE2D1 Antibody, FITC conjugated
Biotin	CSB-PA025443DD01HU	UBE2D1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4.
基因功能參考文獻：
1. The anaphase-promoting complex/cyclosome C activity in human cells is tuned by the combinatorial use of three E2 ubiquitin-conjugating enzymes, namely UBE2C, UBE2S, and UBE2D. PMID: 26904940
2. Data show that ubiquitin E2 enzymes UBE2D1/2/3 and E3 ligase RNF138 accumulate at DNA-damage sites and act at early resection stages by promoting CtIP protein ubiquitylation and accrual. PMID: 26502057
3. The Asp17 mutation in MDM2 stimulated its discharge of the UBCH5a-ubiquitin thioester adduct. PMID: 25543083
4. The SMURF2:UBCH5 complex is critical in maintaining KRAS protein stability. PMID: 24709419
5. Biochemical characterization of recombinant UBTD1 and UBE2D demonstrated that the two proteins form a stable, stoichiometric complex that can be purified to near homogeneity. PMID: 24211586
6. crystal structure of the dimeric RING domain of rat RNF4 in complex with E2 (UbcH5A) linked by an isopeptide bond to ubiquitin PMID: 22842904
7. These data demonstrate that the ability of ICP0 to interact with cellular E2 ubiquitin-conjugating enzyme UBE2D1 is fundamentally important for its biological functions during HSV-1 infection. PMID: 22438555
8. identify the IDOL-UBE2D complex as an important determinant of LDLR activity, and provide insight into molecular mechanisms underlying the regulation of cholesterol uptake PMID: 21685362
9. This structure reveals an interaction between the ubiquitin surface flanking K11 and residues adjacent to the E2 catalytic cysteine and suggests a possible role for this surface in formation of K11 linkages. PMID: 21396940
10. The authors demonstrate that c-IAP1 and UbcH5 family promote K11-linked polyubiquitination of receptor-interacting protein 1 (RIP1) in vitro and in vivo. PMID: 21113135
11. Whereas UbcH5(A, B and C) is highly efficient in converting IkBa into monoubiquitinated forms, Cdc34 drives ubiquitin (Ub)-Ub conjugation PMID: 20347421
12. conformational changes in CHIP upon binding of Hsp70, Hsp90, and their respective C-terminal EEVD peptides, and in complex with the different E2 ubiquitin-conjugating enzymes UbcH5a and Ubc13 PMID: 20146531
13. UbcH5A is up-regulated in the liver of iron-overloaded patients with hereditary hemochromatosis, but in vitro studies failed to show regulation in response to iron loading or chelation. Earlier in vivo mRNA expression data for SFT might be UbcH5A. PMID: 12480712
14. comparison of the regional distribution of SFT/UbcH5A and DMT1 mRNA in the adult brain PMID: 15139022
15. Ro52 has both cytoplasmic and nuclear substrates, and mediates ubiquitination through UBE2D1 in the cytoplasm and through UBE2E1 in the nucleus. PMID: 18845142
16. Catalytically active Ubc5 is required for IRF3 activation by viral infection. PMID: 19854139
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亞細胞定位：

Cytoplasm.
蛋白家族：

Ubiquitin-conjugating enzyme family
組織特異性：

Ubiquitous. Up-regulated in livers of iron-overloaded patients with hereditary hemochromatosis.
數據庫鏈接：

HGNC: 12474

OMIM: 602961

KEGG: hsa:7321

STRING: 9606.ENSP00000363019

UniGene: Hs.129683

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