UBAP2L Antibody

中文名稱：

UBAP2L兔多克隆抗體
貨號：

CSB-PA622754LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA622754LA01HU diluted at 1:400 and staining in paraffin-embedded human ovarian cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of MCF-7 cells with CSB-PA622754LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) UBAP2L Polyclonal antibody
Uniprot No.：

Q14157
基因名：

UBAP2L
別名：

FLJ42300 antibody; KIAA0144 antibody; NICE 4 antibody; NICE4 antibody; Protein NICE-4 antibody; Protein NICE4 antibody; Ubap2l antibody; Ubiquitin associated protein 2 like antibody; Ubiquitin-associated protein 2-like antibody; UBP2L_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Ubiquitin-associated protein 2-like protein (104-252AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，UBAP2L Antibody (CSB-PA622754LA01HU)，的標記方式是Non-conjugated。對于UBAP2L Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA622754LB01HU	UBAP2L Antibody, HRP conjugated	ELISA
FITC	CSB-PA622754LC01HU	UBAP2L Antibody, FITC conjugated
Biotin	CSB-PA622754LD01HU	UBAP2L Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:200-1:500
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs). Required for efficient formation of stress granules.
基因功能參考文獻：
1. UBAP2L plays an oncogenic role in HCC, and knockdown of its expression significantly inhibits HCC growth and metastasis, which may be related to the regulation of PI3K/AKT and P53 signaling pathways by UBAP2L. PMID: 30291221
2. High UBAP2L expression is associated with breast cancer. PMID: 29196913
3. UBAP2L was overexpressed in HCC, and patients with high UBAP2L expression had unfavorable prognosis. PMID: 28981479
4. UBAP2L is amplified in 15% of human primary lung adenocarcinoma specimens. Such patients express higher levels of UBAP2L and show a reduction in survival when compared with those who do not have this gene amplification. PMID: 28754713
5. UBAP2L plays a critical role in maintenance of the metastatic ability of Hepatocellular Carcinoma Cells cells via SNAIL1 Regulation and is predictive of a poor clinical outcome. PMID: 28334716
6. These results suggest that UBAP2L has a key role in glioma cell growth, and may act as an oncogene to promote malignant glioma development. PMID: 26310274
7. arginine residues in the RGG/RG motif of UBAP2L were directly methylated by PRMT1. RGG/RG motif of UBAP2L is essential for the proper alignment of chromosomes. PMID: 26381755
8. Knockdown of UBAP2L in prostate carcinoma inhibited cell proliferation, migration, and colony formation ability, and blocked cell cycle progression. PMID: 25069639
9. Two different BMI1-containing PcG complexes regulate hematopoietic stem cell activity, which are distinguishable by the presence of UBAP2L. PMID: 25185265
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亞細胞定位：

Cytoplasm, Stress granule.
組織特異性：

Ubiquitous.
數據庫鏈接：

HGNC: 29877

OMIM: 616472

KEGG: hsa:9898

STRING: 9606.ENSP00000355343

UniGene: Hs.490551

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