Trim21 Antibody, Biotin conjugated
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中文名稱：Trim21兔多克隆抗體, Biotin偶聯
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貨號：CSB-PA733816LD01MO
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Mus musculus (Mouse) Trim21 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：Trim21 antibody; Ro52 antibody; Ssa1 antibody; E3 ubiquitin-protein ligase TRIM21 antibody; EC 2.3.2.27 antibody; 52 kDa Ro protein antibody; 52 kDa ribonucleoprotein autoantigen Ro/SS-A antibody; RING-type E3 ubiquitin transferase TRIM21 antibody; Ro(SS-A) antibody; Sjoegren syndrome type A antigen antibody; SS-A antibody; Tripartite motif-containing protein 21 antibody
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宿主：Rabbit
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反應種屬：Mouse
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免疫原：Recombinant Mouse E3 ubiquitin-protein ligase TRIM21 protein (1-470AA)
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免疫原種屬：Mus musculus (Mouse)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these proteins is their ability to bind HY RNAs.2. Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1 and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of IRF3, hence attenuating type I interferon (IFN)-dependent immune responses. Represses the innate antiviral response by facilitating the formation of the NMI-IFI35 complex through 'Lys-63'-linked ubiquitination of NMI.
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亞細胞定位：Cytoplasm. Cytoplasmic vesicle, autophagosome. Nucleus. Cytoplasm, P-body.
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蛋白家族：TRIM/RBCC family
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數據庫鏈接：
STRING: 10090.ENSMUSP00000033264
UniGene: Mm.321227
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