TXNL1 Antibody

說明書

產品詳情

Uniprot No.：

O43396
基因名：

TXNL1
別名：

32 kDa thioredoxin related protein antibody; 32 kDa thioredoxin-related protein antibody; Thioredoxin like 1 antibody; Thioredoxin like 32kD antibody; Thioredoxin like 32kDa antibody; Thioredoxin like protein 1 antibody; Thioredoxin related 32 kDa protein antibody; Thioredoxin-like protein 1 antibody; TRP 32 antibody; TRP32 antibody; TRxL antibody; TXL 1 antibody; TXL antibody; TXL1 antibody; TXN L1 antibody; TXNL 1 antibody; TXNL antibody; Txnl1 antibody; TXNL1_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human TXNL1
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Active thioredoxin with a redox potential of about -250 mV.
基因功能參考文獻：
1. TXNL1 is a novel regulatory molecule that inhibits cisplatin resistance in gastric cancer cells. PMID: 24525731
2. Distinct protein expression patterns, affecting TXNL1 and HDAC2, distinguish aneuploid with poor prognosis from diploid colorectal cancers. PMID: 21290163
3. Solution structure of the C-terminal DUF1000 domain of the human thioredoxin-like 1 protein. PMID: 20455272
4. results imply that TRP-1 is a mammalian thioredoxin and plays as a transcriptional repressor through direct binding to the transcription factor B-Myb PMID: 16231315
5. TXNL1 acts as an effector of oxidants or a redox sensor by converting redox changes into changes of GDI capacity to capture Rab5, which in turn modulates fluid phase endocytosis PMID: 17987124
6. Txnl1 is the first example of a direct connection between protein reduction and proteolysis, two major intracellular protein quality control mechanisms. PMID: 19349277
7. TRP32 was identified as a novel subunit of the 26 S proteasome. PMID: 19349280
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亞細胞定位：

Cytoplasm. Nucleus. Note=At least 85% of the cellular TXNL1 is proteasome-associated.
組織特異性：

Ubiquitous.
數據庫鏈接：

HGNC: 12436

OMIM: 603049

KEGG: hsa:9352

STRING: 9606.ENSP00000217515

UniGene: Hs.114412

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