TUBA4A Antibody, Biotin conjugated

說明書

中文名稱：

TUBA4A兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA09499D0Rb
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) TUBA4A Polyclonal antibody
Uniprot No.：

P68366
基因名：

TUBA4A
別名：

Alpha-tubulin 1 antibody; ALS22 antibody; B ALPHA 1 antibody; bA408E5.3 antibody; H2 ALPHA antibody; Hum a tub1 antibody; Hum a tub2 antibody; LIS3 antibody; MGC171407 antibody; MGC55332 antibody; TBA4A_HUMAN antibody; Testis-specific alpha-tubulin antibody; TUBA1 antibody; TUBA1A antibody; tuba1l antibody; Tuba4a antibody; Tubulin alpha 1 chain antibody; Tubulin alpha antibody; Tubulin alpha-1 chain antibody; tubulin alpha-1B chain antibody; Tubulin alpha-4A chain antibody; Tubulin H2-alpha antibody; Tubulin, alpha 1 (testis specific) antibody; tubulin, alpha 1, like antibody; Tubulin, alpha 4a antibody; Tubulin, alpha, testis-specific antibody; Tubulin, alpha-1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Tubulin alpha-4A chain protein (20-183AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
基因功能參考文獻：
1. Data indicate a microRNA-1825/TBCB/TUBA4A pathway as a putative pathogenic cascade in both familial ALS (fALS) and both sporadic (sALS). PMID: 30030593
2. The elevated selenium species levels in the TUBA4A patient may have a genetic etiology and/or represent a pathogenic pathway through which this mutation favors disease onset. PMID: 28478440
3. alphaTubulin expression might be an independent prognostic factor for pancreatic cancer after surgical resection PMID: 27447976
4. Its mutations were seen in patients with ALS and frontotemporal dementia. PMID: 28069311
5. TUBA4A mutations are not associated with FTD. PMID: 26675813
6. In conclusion, our current results did not find an association between TUBA4A and ALS in Chinese patients, and further studies will be required. PMID: 26465396
7. This study mutational screening revealed the presence of four novel heterozygous variants of TUBA4A mutation in four sporadic amyotrophic lateral sclerosis. PMID: 25893256
8. Data show that overexpression of the 14-3-3sigma isoform resulted in a disruption of the tubulin cytoskeleton mediated by binding Tau protein. PMID: 26103986
9. TUBA4A mutants destabilize the microtubule network, diminishing its repolymerization capability PMID: 25374358
10. TUBA4A is significantly increased in spermatazoa from men with azoospermia. PMID: 24268707
11. The results suggested that cytoskeletal alterations in the amygdala determined by tubulin seem to be involved in the pathophysiology of drug addiction PMID: 20686780
12. Subunits of alphaB crystallin that exchange dynamically with the alphaB crystallin complex can interact with tubulin subunits to regulate the equilibrium between tubulin and microtubules. PMID: 20668689
13. increased levels in paclitaxel-resistant breast cancer cells PMID: 12054644
14. Some protein-protein interactions in rafts were disrupted in 3-nitrotyrosine-containing proteins, e.g. caveolin-1 was dissociated from a complex with flotillin-1 and alpha-tubulin. PMID: 15934946
15. Our results suggest that MIZIP might play an important role in mammalian cells by associating with tubulin and thus might provide a link between MCHR1 and tubulin functions. PMID: 16039987
16. These results provide the first characterisation of endogenously nitrated tubulin from human tumour samples. PMID: 16257120
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相關疾?。?/div>
Amyotrophic lateral sclerosis 22, with or without frontotemporal dementia (ALS22)
亞細胞定位：

Cytoplasm, cytoskeleton.
蛋白家族：

Tubulin family
數據庫鏈接：

HGNC: 12407

OMIM: 191110

KEGG: hsa:7277

STRING: 9606.ENSP00000248437

UniGene: Hs.75318

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