TSPYL2 Antibody
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中文名稱：TSPYL2兔多克隆抗體
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貨號：CSB-PA120313
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規格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA120313(TSPYL2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200) -
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA120313(TSPYL2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
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其他：
產品詳情
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Uniprot No.：
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基因名：TSPYL2
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別名：CASK interacting nucleosome assembly protein antibody; CDA1 antibody; Cell division autoantigen 1 antibody; Cell division autoantigen 1 nucleolar protein antibody; CTCL tumor antigen se20-4 antibody; CTCL-associated antigen se20-4 antibody; Cutaneous T-cell lymphoma-associated antigen se20-4 antibody; DENTT antibody; Differentially-expressed nucleolar TGF-beta1 target protein antibody; HRIHFB2216 antibody; NP79 antibody; Nuclear protein of 79 kDa antibody; Testis-specific Y-encoded-like protein 2 antibody; TSPX antibody; TSPY-like protein 2 antibody; TSPYL2 antibody; TSYL2_HUMAN antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthetic peptide of Human TSPYL2
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產品提供形式：Liquid
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應用范圍：ELISA,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:1000-1:5000 IHC 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression.
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基因功能參考文獻：
- Genome-wide polysome profiling shows that hCINAP selectively modulates cancer-associated translatome to promote malignancy. PMID: 27477389
- Aortic CDA1 expression was downregulated approximately 70% within biopsies from human abdominal aortic aneurysms. PMID: 29311219
- TSPY and TSPX exert opposing effects on the transactivation functions of AR and AR-Vs important for various physiological and disease processes sensitive to male sex hormone actions, thereby not only affecting the pathogenesis of male-specific prostate cancer but also likely contributing to sex differences in the health and diseases of man. PMID: 28169398
- the extent of the duplicated regions in each case encompassing a minimum of three known disease genes TSPYL2, KDM5C and IQSEC2, is reported. PMID: 26059843
- homozygous Asp3779Asn and a hemizygous Ile262Met mutations in the LRP2 and TSPYL2 genes, respectively, in a Pakistani family with two boys affected with mild nonsyndromic intellectual disability PMID: 26529358
- Authors demonstrate that human coilin-interacting nuclear ATPase protein (hCINAP) is a novel negative regulator in NF-kappaB signaling by deactivating IkappaB kinase (IKK) complex. PMID: 26089539
- TSPYL2 is an essential component of the REST/NRSF transcriptional complex for TGFbeta signaling activation PMID: 25613376
- Atrial fibrillation can result in alterations in atrial structure and architecture that make the atrial myocardium more susceptible to the maintenance of the arrhythmia. PMID: 25142742
- The oncogenic events leading to an ectopic activation of TSPY and/or inactivating mutation/epigenetic silencing of TSPX could collectively contribute to the sexual dimorphism(s) in HCC and related liver cancers in male-biased manners. PMID: 25017435
- More importantly, RPS14 was specifically modified with NEDD8 and hCINAP inhibited RPS14 NEDDylation by recruiting NEDD8-specific protease 1 PMID: 23246961
- hCINAP may not simply regulate nucleotide homeostasis, but may have broader functionality, including control of Cajal body assembly and disassembly PMID: 22038794
- TSPX is principally expressed in Sertoli cells in the human testis. PMID: 21204751
- knockdown of CINAP expression results in marked reduction of histone transcription, lower levels of U small nuclear RNAs (U1, U2, U4, and U5), and a loss of cell viability PMID: 20186459
- hCINAP is a novel coilin-interacting protein encoded by a transcript from the transcription factor TAFIID32 locus PMID: 16079131
- Overexpression of cell division autoantigen-1 (CDA1) slowed parasite growth and induced expression of bradyzoite-specific proteins. Results showed that changes in host cell transcription can influence the molecular environment for bradyzoite development. PMID: 17069459
- CDA1 induces p53- and MEK/ERK1/2 MAPK-dependent expression of p21 by acting through the p53 responsive element in the p21 promoter and this contributes to its antiproliferative activity PMID: 17317670
- a role for DENTT as a suppressor of the tumorigenic phenotype. PMID: 18381359
- This paper characterizes monkey DENTT cDNA and makes a comparison with human and mouse DENTT PMID: 15823505
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亞細胞定位：Nucleus. Cytoplasm.
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蛋白家族：Nucleosome assembly protein (NAP) family
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組織特異性：Ubiquitously expressed, with highest levels in brain, testis and heart, and lowest levels in liver and pancreas.
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數據庫鏈接：
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