TSN Antibody
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中文名稱：TSN兔多克隆抗體
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貨號：CSB-PA004327
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規(guī)格：￥1090
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圖片：
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Western Blot analysis of Jurkat cells using Translin Polyclonal Antibody
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：TSN
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別名：BCLF 1 antibody; BCLF1 antibody; Component 3 of promoter of RISC antibody; RCHF1 antibody; recombination hotspot associated factor antibody; recombination hotspot binding protein antibody; rehf 1 antibody; REHF1 antibody; TBRBP antibody; Translin antibody; TRSLN antibody; TSN antibody; TSN_HUMAN antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Synthesized peptide derived from the Internal region of Human Translin.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產(chǎn)品提供形式：Liquid
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應用范圍：WB, IHC, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:40000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關產(chǎn)品
靶點詳情
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功能：DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.; Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.
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基因功能參考文獻：
- Translin and Trax control telomere-associated transcript levels in human cells in a telomere-specific fashion. PMID: 27183912
- results indicate that UPF1 can dissociate miRNAs from their mRNA targets, making the miRNAs susceptible to Tudor-staphylococcal/micrococcal-like nuclease (TSN)-mediated miRNA decay. PMID: 28827400
- These findings indicate that miRNA depletion in dicer deficiency is due to the combined loss of miRNA-generating activity and catabolic function of TN/TX. PMID: 25457613
- this study argues against a mechanism by which translin octamers may "dissociate and reassemble" upon RNA binding and report a novel "open"-barrel structure of human translin revealing a feasible DNA/RNA entryway into the cavity. PMID: 25433126
- The selectivity of PLCbeta toward certain genes lies in the rate at which the RNA is hydrolyzed by C3PO. PMID: 24338081
- The data demonstrates that the configuration of translin and translin-RNA complexes in solution is a dimer of tetramers, which undergoes conformational transitions. PMID: 23980029
- Translin B3 motif, corresponding to TRAX B3 residues, contributes towards its DNA binding activity. PMID: 22427937
- C3PO endonuclease is an asymmetric octamer barrel consisting of six translin and two TRAX subunits which activates RISC by degrading the Ago2-nicked passenger strand of siRNA. PMID: 21552258
- Sedimentation equilibrium studies using fluorescein-labeled single-stranded DNA support a model in which translin forms an annular structure of eight subunits, an oblate ellipsoid that binds single-stranded DNA at chromosomal breakpoints. PMID: 11705401
- study of reactivity of two -SH groups and stidu of proximity of Cys-225 residues PMID: 11876655
- At high enough concentrations, translin binds duplex DNA by selectively loading from the free ends, which apparently results in clamping of strands at the duplex ends. PMID: 12484770
- The core protein of HCV can interact with translin protein. This can partly explain the molecular mechanism for hepatocellular carcinoma and lymphoma caused by HCV PMID: 12532453
- TB-RBP post-transcriptionally stabilizes TRAX and both proteins are needed for normal cell proliferation PMID: 14711818
- structure of human translin at 2.2 A resolution is reported in space group C222; translin forms a tetramer; this suggests that the multimerization of translin is flexible; the flexibility may be related to the binding to DNA/RNA PMID: 15039555
- Results suggest that translin might be involved in the control of recombination at d(GT)n.d(AC)n microsatellites and in telomere maintenance. PMID: 15544804
- Translin "chaperones" Trax and forms heteromeric complex that is DNA binding competent PMID: 15919079
- Results describe a circular dichroism analysis of complexes formed between human translin and the microsatellite and telomeric oligodeoxynucleotides d(GT)(12) and d(TTAGGG)(5). PMID: 16218753
- Human translin exhibits a stable octameric state and binds ssDNA/RNA/dsDNA targets, all of which get attenuated when GTP is added PMID: 16411762
- Findings implicate abnormal dendritic trafficking of BDNF mRNA in the pathophysiology of neuropsychiatric disorders linked to the translin G196A mutation. PMID: 19805324
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亞細胞定位：Cytoplasm. Nucleus.
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蛋白家族：Translin family
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