TSHB Antibody, Biotin conjugated

說明書

中文名稱：

TSHB兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA11769D0Rb
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) TSHB Polyclonal antibody
Uniprot No.：

P01222
基因名：

TSHB
別名：

TSHBThyrotropin subunit beta antibody; Thyroid-stimulating hormone subunit beta antibody; TSH-B antibody; TSH-beta antibody; Thyrotropin beta chain antibody; Thyrotropin alfa antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Thyrotropin subunit beta protein (21-132AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Indispensable for the control of thyroid structure and metabolism.
基因功能參考文獻：
1. Serum macro TSH level is associated with sleep quality in patients with cardiovascular risks. PMID: 28287185
2. present the cases of two siblings with a novel mutation of TSHB. One of them was c.40A>G (rs10776792) which is a very common variation that is also seen in healthy individuals, the other was c.94G>A at codon 32 of exon 2 which resulted in a change from glutamic acid to lysine (p.E32K PMID: 28515030
3. The serum levels of IL-8, MIP-1 alpha, MIP-1 beta, MMP-8, Resistin, FLRG, and BCAM were significantly higher in breast cancer patients, but LAP and TSH-beta levels were lower. PMID: 26898119
4. results provide novel evidence of TSHB as a paracrine factor that is modulated in parallel with cholesterol metabolism in human adipose tissue PMID: 28646016
5. In hyperthyroidism, bone marrow resident macrophages have the potential to exert enhanced osteoprotective effects by oversecreting a TSH-beta splice variant. PMID: 27300765
6. In the context of metabolic syndrome, a higher TSH within the euthyroid range confers an increased leptin/adiponectin ratio, a proposed marker of atherosclerosis susceptibility and adipocyte dysfunction. PMID: 28077136
7. the distribution of 1(st) trimester TSH and evaluate its association with perinatal outcomes and future development of maternal thyrotoxicosis, is reported. PMID: 27351808
8. Data suggest that the subtle thyroid-stimulating hormone (TSH) reduction could possibly reflect minor hypothalamic-pituitary damage. PMID: 26432979
9. analysis of a single nucleotide substitution in TSHbeta related to clinical euthyroidism [family case report] PMID: 25950606
10. Findings defined the immune-derived functional TSHb splice variant that resided in the thyroid of patients with Hashimoto's thyroiditis (HT), which exerted the unique effects on the pathogenesis of the disease. PMID: 26170068
11. Serum TSH was associated with pulse wave velocity on population level when adjusted with age and sex. PMID: 25185682
12. Higher TSH levels are associated with less favorable lipid levels in children PMID: 25781359
13. In cases with isolated central congenital hypothyroidism and undetectably low TSH serum concentrations, a TSHbeta gene deletion should be considered PMID: 25012771
14. Epistasis between single nucleotide polymorphisms within the TSHB and ADAMTS16 genes may increase the risk of premature ovarian failure in Korean women. PMID: 24366283
15. High Thyroid Stimulating Hormone levels are associated with papillary thyroid carcinoma. PMID: 24595799
16. bTSH Induces IL-6 Protein and mRNA in Orbital Fibroblasts and Fibrocytes PMID: 24086448
17. The use of these age-specific reference intervals for TSH, especially in those over 70 years old, would result in the reclassification of many TSH results from "abnormal" to "normal" and avoid unnecessary treatment. PMID: 23345094
18. In Hashimoto's thyroiditis the hTSHbeta splice variant exists in human serum and dimerises with TSHalpha. PMID: 22752807
19. Data suggest that a progressive increase in TSH are predictive factors for thyroid failure in Hashimoto's thyroiditis (HT) patients. PMID: 21981142
20. Data suggest that likelihood of papillary thyroid carcinoma is reduced when serum TSH is lower, as in thyroid autonomy, and increased when serum TSH is higher, as in thyroid autoimmunity. [Meta-Analysis; REVIEW] PMID: 22278420
21. Studies indicate that immune system-derived TSH, in particular, a splice variant of TSHbeta that is preferentially made by cells of the immune system, is produced by a subset of hematopoietic cells that traffic to the thyroid. PMID: 20826543
22. Results suggest that a serum TSH concentration at the lower end of the reference range may be associated with low BMD in men. PMID: 20455884
23. Novel mutations of the TSH-beta subunit gene underlying congenital central hypothyroidism undetectable in neonatal TSH screening. PMID: 20534762
24. we describe two new sibships with isolated congenital central hypothyroidism due to two different homozygous TSHbeta gene mutations (c.Q49X and c.C105fs114X). PMID: 20553196
25. TSHbeta variants C105Vfs114X and Q49X are the most frequent cause of this severe disorder in Europe, now for the first time observed in compound heterozygous state. PMID: 15297803
26. Data suggest that the expression of Pit-1 in cells of the alpha SU-based gonadotropin cell lineage might also lead to the expression of growth hormone, prolactin, and thyroid-stimulating hormone beta subunit. PMID: 16133148
27. N-CoR and TRbeta cooperate in the regulation of the TSHbeta gene and this ligand-dependent repression is mediated by the LXXLL motif in N-CoR PMID: 16216492
28. Serum TSH is frequently suppressed after treatment with antithyroid drugs. PMID: 17954417
29. In a cohort of pregnant women without overt thyroid dysfunction, the risk of child loss increased with higher levels of maternal TSH. PMID: 19273570
30. Human pituitary, thyroid, and mononuclear leukocytes express a TSHbeta isoform that is analogous to the mouse TSHbeta isoform, consisting of a 27 nucleotide portion of intron 2 and all of exon 3, coding for 71.2% of the native human TSHbeta polypeptide. PMID: 19364510
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亞細胞定位：

Secreted.
蛋白家族：

Glycoprotein hormones subunit beta family
數據庫鏈接：

HGNC: 12372

OMIM: 188540

KEGG: hsa:7252

STRING: 9606.ENSP00000256592

UniGene: Hs.406687

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