TSC22D1 Antibody, Biotin conjugated

說明書

中文名稱：

TSC22D1兔多克隆抗體, Biotin偶聯(lián)
貨號：

CSB-PA623011LD01HU
規(guī)格：

￥880
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) TSC22D1 Polyclonal antibody
Uniprot No.：

Q15714
基因名：

TSC22D1
別名：

Cerebral protein 2 antibody; DKFZp686O19206 antibody; Hucep 2 antibody; Hucep2 antibody; KIAA1994 antibody; MGC17597 antibody; OTTHUMP00000040978 antibody; Ptg 2 antibody; Regulatory protein TSC 22 antibody; Regulatory protein TSC-22 antibody; Regulatory protein TSC22 antibody; RP11 269C23.2 antibody; T22D1_HUMAN antibody; TGFB stimulated clone 22 homolog antibody; TGFB-stimulated clone 22 homolog antibody; TGFB1I4 antibody; TGFbeta stimulated clone 22 antibody; Transcriptional regulator TSC 22 antibody; Transforming growth factor beta 1 induced transcript 4 antibody; Transforming growth factor beta 1 induced transcript 4 protein antibody; Transforming growth factor beta stimulated protein TSC 22 antibody; Transforming growth factor beta-1-induced transcript 4 protein antibody; TSC 22 antibody; TSC22 antibody; TSC22 domain family 1 isoform 2 antibody; TSC22 domain family member 1 antibody; TSC22 domain family protein 1 antibody; TSC22D1 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human TSC22 domain family protein 1 protein (1-144AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter.
基因功能參考文獻(xiàn)：
1. TSC22 could suppress tumor by inhibiting cell proliferation in colorectal cancer cell lines. Multivariate Cox regression analysis confirmed TSC22 expression as independent predictors of the OS in CRC patients PMID: 29481799
2. TSC-22 acts as a tumor suppressor by safeguarding p53 from poly-ubiquitination mediated-degradation. PMID: 22870275
3. we report that induced Tsc-22 leads to enhancement of TGF-beta-dependent signaling and enhancement is blocked by expression of a dominant-negative Tsc-22 mutant PMID: 21881999
4. Differential regulation of antagonistic TSC22D1 variants is required for the establishment of oncogene-induced cellular senescence. PMID: 21448135
5. Results support role of TSC22D1 as an enhancer of CNP transcription and suggest that TGF-beta-induced upregulation of CNP expression in smooth muscle may be mediated in part by increased transcription of TSC22D1. PMID: 20802130
6. Long form of TSC22DF is evolutionarily conserved and has growth-regulating potential. PMID: 20149264
7. Leucine Zipper structure of TSC22 markedly inhibits the anchorage independent growth of salivary gland cancer cells PMID: 11836610
8. TSC-22 is an important downstream component of PPARgamma and TGF-beta signaling during intestinal epithelial cell differentiation PMID: 12468551
9. findings suggest that the TSC-22 gene (-396) A allele is associated with an increasing risk of diabetic nephropathy PMID: 12757981
10. Upregulation of TSC-22 mRNA by TGF-beta 1 is achieved by mRNA stabilization. PMID: 12767908
11. Tsc-22 modulates the TGF-beta-dependant signaling pathway and binds to and modulate the transcriptional activity of Smad3 and Smad4. It has effect on cellular differentiation PMID: 15881652
12. expression of TSC-22 in prostate is restricted to basal layer; maybe useful marker for differentation between normal and malignant acinar epithelium of prostate PMID: 16106424
13. TSC-22 is a potential tumor suppressor that is upregulated by Flt3-D835V but not Flt3-ITD PMID: 17690703
14. Expression of TSC-22 was frequently observed in the tumor cells with differentiated-phenotypes, although rarely in the cells with growing potentials. PMID: 18288391
15. interaction between fortilin and TSC-22 prevents apoptosis via the destabilization of TSC-22 in ovarian carcinoma cells PMID: 18325344
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亞細(xì)胞定位：

Cytoplasm. Nucleus.
蛋白家族：

TSC-22/Dip/Bun family
組織特異性：

Widely expressed in fetal and adult tissues.
數(shù)據(jù)庫鏈接：

HGNC: 16826

OMIM: 607715

KEGG: hsa:8848

STRING: 9606.ENSP00000397435

UniGene: Hs.436383

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