TRPV3 Antibody, FITC conjugated

說明書

中文名稱：

TRPV3兔多克隆抗體, FITC偶聯
貨號：

CSB-PA854113LC01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) TRPV3 Polyclonal antibody
Uniprot No.：

Q8NET8
基因名：

TRPV3
別名：

TRPV3; Transient receptor potential cation channel subfamily V member 3; TrpV3; Vanilloid receptor-like 3; VRL-3
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Transient receptor potential cation channel subfamily V member 3 protein (1-118AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen).
基因功能參考文獻：
1. Data suggest that Thr264 in TRPV3 is key ERK1 phosphorylation site mediating EGFR-induced sensitization of TRPV3 to stimulate signaling pathways involved in regulating skin homeostasis. (TRPV3 = transient receptor potential cation channel subfamily V member-3; ERK1 = extracellular signal-regulated kinase-1; EGFR = epidermal growth factor receptor) PMID: 29084846
2. This study identified a direct regulatory effect of MBTPS2 on TRPV3 which can partially contribute to the overlapping clinical features of IFAP and Olmsted syndromes under a common signaling pathway. PMID: 28717930
3. TRPV3 may contribute to pruritus in burn scars through TSLP. PMID: 29140280
4. the expression of transient receptor potential vanilloid-1 (TRPV1), transient receptor potential vanilloid-2 (TRPV2) and transient receptor potential vanilloid-3 (TRPV3) channels in native human odontoblasts, was examined. PMID: 28905239
5. TRPV3 was highly expressed in the infiltrating eosinophils and mucosal epithelium of the nasal polyps of ECRS, and further that the more severe the refractoriness was after surgery, the higher the TRPV3 expression was in nasal polyps. PMID: 28462829
6. Data indicate that the restoration of a single residue that is apparently missing in the use-dependent homologs could largely eliminate the use dependence of heat sensitivity of vanilloid receptor transient receptor potential 3 (TRPV3). PMID: 28154143
7. TRPV3 mutants causing Olmsted Syndrome induce impaired cell adhesion and nonfunctional lysosomes PMID: 27754757
8. *We describe two cases of Olmsted-like syndrome in a Mongolian family. *The underlying cause was a previously undescribed G573V point mutation in TRPV3. PMID: 27273692
9. The results of the present study show that polymorphism of TRPV3 contributed towards symptom severity in FM. PMID: 27079220
10. A novel mutation in TRPV3 gene causes atypical familial Olmsted syndrome in a Chinese family. PMID: 26902751
11. High Transient receptor potential vanilloid 3 protein expression could promote the proliferation of lung cancer cells. Transient receptor potential vanilloid 3 inhibition decreased [Ca2+]i of lung cancer cells and cell cycle arrest at the G1/S boundary. PMID: 27023518
12. these data suggest that TRPV3 sparklets cause dilation of cerebral parenchymal arterioles by activating IK and SK channels in the endothelium PMID: 26453324
13. TRPV3 missense mutation identified as a cause of the rare Olmsted syndrome. PMID: 26067147
14. TPRV3 was significantly elevated in the epidermis of burn scars with pruritus. PMID: 24695993
15. Study illustrates the antiadipogenic role of TRPV3 in the adipocytes. PMID: 25774551
16. this study provides powerful tools to broaden our understanding of ligand interaction with TRPV channels, and the availability of purified human TRPV3 opens up perspectives for further structural and functional studies PMID: 25829496
17. A mutation in TRPV3 causes focal palmoplantar keratoderma in a Chinese family. PMID: 25285920
18. Demonstrate similarities but also notable differences in TRPV3 pharmacology between recombinant and native systems. PMID: 23848361
19. a TRPV3 mutation has a role in Olmsted syndrome [case report] PMID: 24463422
20. TRPV3 missense mutation found in patient with Olmsted syndrome. PMID: 24452206
21. TRPV3-ARD with characteristic finger 3 loop likely plays an important role in channel function and pharmacology. PMID: 24248473
22. TRPV3 has roles in skin physiology and in certain skin diseases [review] PMID: 23800054
23. The Olmsted syndrome patient was found to harbour a previously undescribed 1718G-C transversion in TRPV3, causing a G573A point mutation with immunological dysregulation function. PMID: 23692804
24. TRPV3 is a therapeutic target for itch PMID: 22475759
25. Nucleotide sequencing of five additional affected individuals also revealed missense mutations in TRPV3. PMID: 22405088
26. Nominal association was confirmed for TRPV3 rs7217270 in migraine with aura and TRPV1 rs222741 in the overall migraine group. PMID: 22162417
27. It was concluded that the sensitization of TRPV3 is intrinsic to the channel itself and occurs as a result of hysteresis of channel gating. PMID: 22006988
28. TRPV3 channel is expressed in skin, its likely role is to detect noxious cold temperatures. PMID: 21490957
29. PI(4,5)P(2)-dependent modulation of TRPV3 activity represents an attractive mechanism for acute regulation of keratinocyte signaling cascades that control cell proliferation and the release of autocrine and paracrine factors. PMID: 21321070
30. Farnesyl pyrophosphate is the firstly identified endogenous TRPV3 activator that causes nociception PMID: 20395302
31. A multiligand binding site for ATP and calmodulin previously identified in the TRPV1 ankyrin repeat domain is conserved in TRPV3 and TRPV4, but not TRPV2. PMID: 19864432
32. member of the vanilloid channel family that is expressed in skin, tongue, dorsal root ganglion, trigeminal ganglion, spinal cord and brain; a calcium-permeable temperature-sensitive cation channel PMID: 12077604
33. temperature-sensitive (but capsaicin-insensitive) vanilloid receptor-like protein; may represent an additional vanilloid receptor subunit involved in the formation of heteromeric vanilloid receptor channels PMID: 12077606
34. Ca(2+) inhibits TRPV3 from both the extracellular and intracellular sides. The inhibition is sequentially reduced, appearing as sensitization to repetitive stimulations. PMID: 18178557
35. vanilloid type 3 (TRPV3) channel is crucially involved in pruritic dermatitis [review] PMID: 19209153
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相關疾病：

Olmsted syndrome (OLMS); Palmoplantar keratoderma, non-epidermolytic, focal 2 (FNEPPK2)
亞細胞定位：

Membrane; Multi-pass membrane protein.
蛋白家族：

Transient receptor (TC 1.A.4) family, TrpV subfamily, TRPV3 sub-subfamily
組織特異性：

Abundantly expressed in CNS. Widely expressed at low levels. Detected in dorsal root ganglion (at protein level). Expressed in the keratinocyte layers of the outer root sheath and, to lesser extent, to the matrix of the hair follicles (at protein level).
數據庫鏈接：

HGNC: 18084

OMIM: 607066

KEGG: hsa:162514

STRING: 9606.ENSP00000461518

UniGene: Hs.446255

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